Journal of the Chemical Society. Perkin Transactions 2 (2001) p. 2407 - 2414 (1996)
Update date:2022-08-05
Topics:
Hoffmann, Reinhard W.
Colin Kahrs
Schiffer, Jan
Fleischhauer, Joerg
(R,R)-Bis(tetrahydropyran-2-yl)methane 4 along with its racemate have been synthesized. MM3 calculations suggest that the conformer 4a should be populated to ca. 85% in the conformer equilibrium. Analysis of the 1H NMR coupling constants show that one conformer predominates by about 9:1. That this is the conformer 4a is shown by various NMR techniques, as well as by comparison of calculated with measured CD spectroscopic data. The study is extended to the methyl-substituted bis(tetrahydropyranyl)methanes 21 and 23 which show, as predicted from MM3 calculations, essentially mono-conformational behaviour.
View MoreBeijing Wisdom Chemicals Co., Ltd.
Contact:+86-10-52350335
Address:F2, BLDG 19, Liando Valley U, Majuqiao, Tongzhou District, Beijing, China
Nanjing Chemipioneer Pharma&Tech Co.,Ltd
website:http://www.chemipioneer.com.cn
Contact:+86-25-52685700
Address:Room 305，A Block，Biological-Medicine Building，Business Start-up Center，Xin-ke 1st Road, High-tech development zone，Nanjing city，Jiangsu Province, China
QINGDAO DEVELOP chemistry Co.,Limited
Contact:+86-532-85807910
Address:98#Nanjing Road, Qingdao, China 266071
TIANJIN ZHONGXIN CHEMTECH CO.,LTD.
Contact:86-022-89880739
Address:10B, Pan China International Center, No. 931 YingKou Road, TangGu, Tianjin, China, 300451
Chengdu Sino-Strong Pharmaceutical Co.,Ltd.
website:http://www.sino-strong.com.cn
Contact:+86-28-82666753
Address:459 West haike road,Cross-straits technological industry park, Wenjiang district,Chengdu, P.R.China
Doi:10.1016/S0040-4020(01)00159-4
(2001)Doi:10.1021/jm9701785
(1997)Doi:10.1021/ja01156a098
(1951)Doi:10.1055/s-1997-1497
(1997)Doi:10.1016/j.tetlet.2012.06.044
(2012)Doi:10.1002/cmdc.201600580
(2017)
