A new framework for the cycloaromatization of enediynes under mild conditions

DOI: 10.1016/S0040-4039(97)01263-X

Source and publish data:

Tetrahedron Letters p. 5583 - 5586 (1997)

Update date:2022-07-30

Topics:

Authors:

Semmelhack

Gu, Yansong

Ho, Douglas M.

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Article abstract of DOI:10.1016/S0040-4039(97)01263-X

An enediyne unit in a bicyclo[8.3.0] framework with a trans ring fusion has been designed, synthesized, and evaluated as a new functional model for the enediyne toxins. The cycloaromatization reaction proceeds with a half-life time of 13-14 hr at 25°C.

Full text of DOI:10.1016/S0040-4039(97)01263-X

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