Welcome to LookChem.com Sign In|Join Free

CAS

  • or

113-24-6

Post Buying Request

113-24-6 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

113-24-6 Usage

Description

Sodium pyruvate is the sodium salt of pyruvate. It is frequently supplemented to the cell culture medium to act as a source of energy since it is a key intermediate during the production of the high-energy ATP molecules inside cells. For example, it can be used as a carbon source for bacteria. It may also protect cell against hydrogen peroxide, an oxidant to scavenger oxygen radicals. It is an important metabolic intermediate in many essential metabolic pathways such as carbohydrate metabolism. For example, it is converted into acetyl coenzyme A and enters into the TCA cycle (Kreb’s cycle) in organisms. It is also involved in the amino acid metabolism in organisms.

Chemical Properties

White to slightly yellow crystalline powder. soluble in water, very slightly soluble in ethanol.

Uses

Different sources of media describe the Uses of 113-24-6 differently. You can refer to the following data:
1. Intermediate in sugar metabolism and in enzymatic carbohydrate degradation (alcoholic fermentation) where it is converted to acetaldehyde and CO2 by carboxylase. In muscle, Pyruvic acid (derived from glycogen) is reduced to lactic acid during exertion, which is reoxidized and partially retransformed to glycogen during rest. The liver can convert Pyruvic acid to alanine by amination. A diagnostic agent for Parkinson disease
2. Sodium pyruvate is used in cell culture media as an additional source of energy. It acts as an antioxidant and finds protective effects against oxygen radicals. It serves as an intermediate in many metabolic pathways such as sugar metabolism. It is converted into acetyl coenzyme A and enters the trichloroacetic acid cycle. In addition, it is involved with amino acid metabolism and initiates the Kreb's cycle. It plays an important role as a free radical scavenger.

Application

Sodium pyruvate has been used:To prepare Bull Tyrode′s albumin-lactate-pyruvate diluent.In pyruvate tolerance test.To prepare oligodendrocyte culture medium.

Preparation

The preparation of sodium pyruvate is as follows:Synthesis of pyruvate, a salt of a compound of formula (II) by ozonolysis of methacrylic acid, a compound of formula (II) A solution of methacrylic acid obtained in Example la or lb (15.31 g, 178 mmol) in dichloromethane/methanol (5 % methanol, 50 ml) was cooled to -78?0C and a stream of ozone was passed through until the solution turned blue. Dimethylsulfide (12.41 g, 200 mmol) was added and the mixture was allowed to reach room temperature. Excess dimethylsulfide was removed by passing a stream of nitrogen through the reaction mixture. The reaction mixture was evaporated in vacuo at 30?0C. To the residue was added water (100 ml) and then slowly added a solution of aq. NaOH (IM, 178 ml). The mixture was concentrated and left for crystallisation at 4 °C. The white crystalline material obtained was filtered and washed with acetone (3x100 ml). Yield: 14.50 g (92 %). Purity: 95 %.

Biological Functions

Sodium pyruvate (α-Ketopropionic acid sodium salt; 2-Oxopropanoic acid sodium salt;Pyruvic acid sodium; C3H3NaO3) as an important endogenous small molecules participates various tissue and organ metabolism processes that is the final product of glycolysis and the starting substrate for the tricarboxylic acid (TCA) cycle, and possesses antioxidant and scavenging free radical effects, thus widely using as buffer, excipient and antioxidant in medicine, diagnostic reagent and medical device. Sodium pyruvate is an endogenous antioxidant and reactive oxygen radical scavenger. In this process, H2O2 or other reactive oxygen radicals are scavenged by sodium pyruvate by a nonenzymatic reaction or an oxidative dephosphorylation, and produce acetate, water and carbon dioxide. Thus, sodium pyruvate can suppress renal cellular injury induced by H2O2, such as lipid peroxidation of rat kidney homogenate, and cytosolic 51Cr release (a marker of cellular injury) from renal epithelial cells induced by H2O2. Thus, sodium pyruvate as effect antioxidant has potential in the clinical medication. Moreover, as effect antioxidant, sodium pyruvate is also as additives used in a vast range of foods and toiletries.

General Description

Sodium pyruvate (SP) is a simplest keto-acid. It crystallizes as very thin plates and belongs to the monoclinic system. Its utility in Knoevenagel condensation carried out in an aqueous medium has been examined. The standard molar enthalpy of formation and molar enthalpy of dissolution of SP at infinite dilution have been obtained. Its efficacy in treating mitochondrial DNA depletion syndromes has been investigated.

Flammability and Explosibility

Notclassified

Biochem/physiol Actions

Sodium pyruvate is known to be an effective therapeutic target for type II citrullinaemia which is characterized by hyperammonaemia. In vivo studies proves that sodium pyruvate has protective function against hemorrhagic shock by preventing lipid peroxidation, NAD+ reduction and cleavage of poly(ADP-ribose) polymerases. Sodium pyruvate is also known to possess anti-inflammatory action and might show improvement in chronic lung disorder.

storage

Sterile filtered commercial solutions of sodium pyruvate are stable up to 24 months, when stored at 2-8 °C.Pyruvic acid polymerizes and decomposes upon standing. It is advised to keep containers tightly sealed.

References

https://en.wikipedia.org/wiki/Sodium_pyruvate Taidi, Behnam, et al. "Effect of carbon source and concentration on the molecular mass of poly (3-hydroxybutyrate) produced by Methylobacterium extorquens and Alcaligenes eutrophus." Applied microbiology and biotechnology 40.6 (1994): 786-790. https://www.alfa.com/zh-cn/catalog/A11148/ http://bio.lonza.com/uploads/tx_mwaxmarketingmaterial/Lonza_BenchGuides_Sodium_Pyruvate_Solution_100mM.pdf

Check Digit Verification of cas no

The CAS Registry Mumber 113-24-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,1 and 3 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 113-24:
(5*1)+(4*1)+(3*3)+(2*2)+(1*4)=26
26 % 10 = 6
So 113-24-6 is a valid CAS Registry Number.
InChI:InChI=1/C3H4O3.Na/c1-2(4)3(5)6;/h1H3,(H,5,6);/q;+1/p-1

113-24-6 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • TCI America

  • (P0582)  Sodium Pyruvate  >97.0%(T)

  • 113-24-6

  • 25g

  • 130.00CNY

  • Detail
  • TCI America

  • (P0582)  Sodium Pyruvate  >97.0%(T)

  • 113-24-6

  • 100g

  • 380.00CNY

  • Detail
  • TCI America

  • (P0582)  Sodium Pyruvate  >97.0%(T)

  • 113-24-6

  • 500g

  • 1,250.00CNY

  • Detail
  • Alfa Aesar

  • (A11148)  Sodium pyruvate, 99%   

  • 113-24-6

  • 50g

  • 486.0CNY

  • Detail
  • Alfa Aesar

  • (A11148)  Sodium pyruvate, 99%   

  • 113-24-6

  • 250g

  • 2182.0CNY

  • Detail
  • Alfa Aesar

  • (A11148)  Sodium pyruvate, 99%   

  • 113-24-6

  • 500g

  • 3989.0CNY

  • Detail
  • Sigma-Aldrich

  • (792500)  Sodiumpyruvate  anhydrous, free-flowing, Redi-Dri, ReagentPlus®, ≥99%

  • 113-24-6

  • 792500-100G

  • 1,723.41CNY

  • Detail
  • Sigma-Aldrich

  • (792500)  Sodiumpyruvate  anhydrous, free-flowing, Redi-Dri, ReagentPlus®, ≥99%

  • 113-24-6

  • 792500-500G

  • 6,170.58CNY

  • Detail
  • Sigma-Aldrich

  • (792500)  Sodiumpyruvate  anhydrous, free-flowing, Redi-Dri, ReagentPlus®, ≥99%

  • 113-24-6

  • 792500-1KG

  • 10,092.42CNY

  • Detail
  • Vetec

  • (V900232)  Sodiumpyruvate  Vetec reagent grade, 98%

  • 113-24-6

  • V900232-100G

  • 128.70CNY

  • Detail
  • Sigma-Aldrich

  • (P2256)  Sodiumpyruvate  ReagentPlus®, ≥99%

  • 113-24-6

  • P2256-10MG

  • 210.60CNY

  • Detail
  • Sigma-Aldrich

  • (P2256)  Sodiumpyruvate  ReagentPlus®, ≥99%

  • 113-24-6

  • P2256-5G

  • 265.59CNY

  • Detail

113-24-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name sodium pyruvate

1.2 Other means of identification

Product number -
Other names PYRUVATE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:113-24-6 SDS

113-24-6Synthetic route

2-oxo-propionic acid
127-17-3

2-oxo-propionic acid

sodium pyruvate
113-24-6

sodium pyruvate

Conditions
ConditionsYield
With sodium formate In ethyl acetate97%
With sodium acetate In ethyl acetate94%
With sodium hydroxide; ethanol; water
poly(methacrylic acid)
79-41-4

poly(methacrylic acid)

sodium pyruvate
113-24-6

sodium pyruvate

Conditions
ConditionsYield
Stage #1: poly(methacrylic acid) With ozone In methanol; dichloromethane at -78℃;
Stage #2: With dimethylsulfide In methanol; dichloromethane at -78 - 20℃;
Stage #3: With sodium hydroxide In water
92%
ethyl 2-hydroxypropionate
97-64-3, 2676-33-7

ethyl 2-hydroxypropionate

sodium pyruvate
113-24-6

sodium pyruvate

Conditions
ConditionsYield
Stage #1: ethyl 2-hydroxypropionate With 9-azabicyclo<3.3.1>nonane-N-oxyl; dihydrogen peroxide In ethyl acetate at 10 - 40℃; for 3h;
Stage #2: With sodium carbonate In water; ethyl acetate at 20℃; for 1h; pH=3 - 4; Reagent/catalyst; Temperature;
55%
L-alanin
56-41-7

L-alanin

sodium phenylphyruvate
114-76-1

sodium phenylphyruvate

A

Phenylalanine
150-30-1

Phenylalanine

B

sodium pyruvate
113-24-6

sodium pyruvate

Conditions
ConditionsYield
With acetate buffer; N(1+)C5His2C16; PL(1+)2C16; copper(II) perchlorate In water at 30℃; for 48h; Kinetics;
S-allyl cysteine
21593-77-1, 49621-03-6

S-allyl cysteine

A

diallyl disulphide
2179-57-9

diallyl disulphide

B

allicin
539-86-6

allicin

C

bis-2-propenyl thiosulfonate
29418-05-1

bis-2-propenyl thiosulfonate

D

sodium pyruvate
113-24-6

sodium pyruvate

Conditions
ConditionsYield
With nitrogen(II) oxide In water for 24h; Ambient temperature; Yield given. Yields of byproduct given;
sodium enol pyruvate
44300-97-2

sodium enol pyruvate

sodium pyruvate
113-24-6

sodium pyruvate

Conditions
ConditionsYield
With sodium hydroxide; iodine; potassium iodide In water at 25℃; Rate constant; Equilibrium constant; other base as reagents;
With phosphate buffer; iodine; potassium iodide at 11℃; Equilibrium constant; Further Variations:; Temperatures; enolization;
sodium pyruvate hydrate
43165-43-1

sodium pyruvate hydrate

sodium pyruvate
113-24-6

sodium pyruvate

Conditions
ConditionsYield
With sodium hydroxide In water at 25℃; Rate constant; Equilibrium constant; other bases or acids reagents;
With phosphate buffer; iodine; potassium iodide at 11℃; Equilibrium constant; Further Variations:; Temperatures; hydration;
sodium lactate
312-85-6

sodium lactate

sodium pyruvate
113-24-6

sodium pyruvate

Conditions
ConditionsYield
With sodium hydroxide; lead(II) nitrate In water Product distribution; modified platinum electrode by lead ad-atoms, effect of pyruvate concentration;
With sodium ruthenate(VI); hexacyanoferrate(III); sodium perchlorate; sodium hydroxide at 30℃; Kinetics; Mechanism;
3‐phosphopyruvate
5824-58-8

3‐phosphopyruvate

A

sodium pyruvate
113-24-6

sodium pyruvate

B

phosphate

phosphate

Conditions
ConditionsYield
With acetate buffer In water at 75℃; Mechanism; Kinetics; Thermodynamic data; different buffers: pH 0.59 to 8.32; kH/kD; different temp.; Ea, ΔH(excit.), ΔS(excit.);
Sodium; (2S,4S,5R,6S)-6-(1,2-dihydroxy-ethyl)-2,4,5-trihydroxy-tetrahydro-pyran-2-carboxylate

Sodium; (2S,4S,5R,6S)-6-(1,2-dihydroxy-ethyl)-2,4,5-trihydroxy-tetrahydro-pyran-2-carboxylate

A

β-D-lyxopyranose
608-47-9

β-D-lyxopyranose

B

sodium pyruvate
113-24-6

sodium pyruvate

Conditions
ConditionsYield
With N-acetylneuraminic acid aldolase at 37℃;
Sodium; (2S,4S,5R,6R)-2,4,5-trihydroxy-6-(1,2,3-trihydroxy-propyl)-tetrahydro-pyran-2-carboxylate

Sodium; (2S,4S,5R,6R)-2,4,5-trihydroxy-6-(1,2,3-trihydroxy-propyl)-tetrahydro-pyran-2-carboxylate

A

β-D-mannose
7322-31-8

β-D-mannose

B

sodium pyruvate
113-24-6

sodium pyruvate

Conditions
ConditionsYield
With N-acetylneuraminic acid aldolase at 37℃;
Conditions
ConditionsYield
With N-acetylneuraminic acid aldolase at 37℃;
L-alanin
56-41-7

L-alanin

pyridoxal hydrochloride
65-22-5

pyridoxal hydrochloride

A

sodium pyruvate
113-24-6

sodium pyruvate

B

pyridoxamine
85-87-0

pyridoxamine

Conditions
ConditionsYield
Stage #1: L-alanin; pyridoxal hydrochloride With sodium acetate; acetic acid In ethanol; water at 50℃; pH=7.15;
Stage #2: In ethanol
sodium 4-phenyl-4-hydroxy-2-oxobutyrate
1138160-36-7

sodium 4-phenyl-4-hydroxy-2-oxobutyrate

A

sodium pyruvate
113-24-6

sodium pyruvate

B

benzaldehyde
100-52-7

benzaldehyde

Conditions
ConditionsYield
With bovine heart L-lactate dehydrogenase; C80H134N14O12; NADH at 30℃; for 14h; pH=8; Kinetics; pH-value; Temperature; Reagent/catalyst; aq. buffer; Enzymatic reaction;
4-hydroxy-2-oxopentanoate
2507-67-7

4-hydroxy-2-oxopentanoate

A

4-hydroxy-2-oxopentanoate

4-hydroxy-2-oxopentanoate

B

sodium pyruvate
113-24-6

sodium pyruvate

C

acetaldehyde
75-07-0

acetaldehyde

Conditions
ConditionsYield
With pyruvate aldolase BphI; manganese(ll) chloride pH=8; aq. buffer;
sodium oxaloacetic acid

sodium oxaloacetic acid

sodium pyruvate
113-24-6

sodium pyruvate

Conditions
ConditionsYield
With L-lactate dehydrogenase; NADH; N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid pH=8; Kinetics; aq. buffer; Enzymatic reaction;
sodium 4-hydroxy-2-oxopentanoate

sodium 4-hydroxy-2-oxopentanoate

A

sodium pyruvate
113-24-6

sodium pyruvate

B

acetaldehyde
75-07-0

acetaldehyde

Conditions
ConditionsYield
With L-lactate dehydrogenase; NADH; manganese(ll) chloride; N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid pH=8; Kinetics; aq. buffer; Enzymatic reaction;
sodium 4-hydroxy-2-oxohexanoate

sodium 4-hydroxy-2-oxohexanoate

A

sodium pyruvate
113-24-6

sodium pyruvate

B

propionaldehyde
123-38-6

propionaldehyde

Conditions
ConditionsYield
With L-lactate dehydrogenase; NADH; manganese(ll) chloride; N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid pH=8; Kinetics; aq. buffer; Enzymatic reaction;
sodium 4-hydroxy-2-oxoheptanoate

sodium 4-hydroxy-2-oxoheptanoate

A

sodium pyruvate
113-24-6

sodium pyruvate

B

butyraldehyde
123-72-8

butyraldehyde

Conditions
ConditionsYield
With L-lactate dehydrogenase; NADH; manganese(ll) chloride; N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid pH=8; Kinetics; aq. buffer; Enzymatic reaction;
sodium 4-(S)-hydroxy-2-oxopentanoate

sodium 4-(S)-hydroxy-2-oxopentanoate

A

sodium pyruvate
113-24-6

sodium pyruvate

B

acetaldehyde
75-07-0

acetaldehyde

Conditions
ConditionsYield
With L-lactate dehydrogenase; NADH; manganese(ll) chloride; N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid at 25℃; pH=8; Kinetics; aq. buffer; Enzymatic reaction;
sodium 4-(R)-hydroxy-2-oxopentanoate

sodium 4-(R)-hydroxy-2-oxopentanoate

A

sodium pyruvate
113-24-6

sodium pyruvate

B

acetaldehyde
75-07-0

acetaldehyde

Conditions
ConditionsYield
With L-lactate dehydrogenase; NADH; manganese(ll) chloride; N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid at 25℃; pH=8; Kinetics; aq. buffer; Enzymatic reaction;
sodium 2-keto-4-hydroxyoctanoate

sodium 2-keto-4-hydroxyoctanoate

A

pentanal
110-62-3

pentanal

B

sodium pyruvate
113-24-6

sodium pyruvate

Conditions
ConditionsYield
With L-lactate dehydrogenase; NADH; manganese(ll) chloride; N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid pH=8; Kinetics; aq. buffer; Enzymatic reaction;
D-(-)-sodium lactate
920-49-0

D-(-)-sodium lactate

sodium pyruvate
113-24-6

sodium pyruvate

Conditions
ConditionsYield
With recombinant D-lactate dehydrogenase from Lactobacillus jensenii 269-3; nicotinamide adenine dinucleotide In aq. buffer at 25℃; pH=8; Kinetics; Concentration; Reagent/catalyst; Temperature; pH-value; Enzymatic reaction;
sodium L-lactate
867-56-1

sodium L-lactate

sodium pyruvate
113-24-6

sodium pyruvate

Conditions
ConditionsYield
With Aerococcus viridans L-lactate oxidase, wild-type, containing oxidized-state FMN cofactor In aq. phosphate buffer at 20℃; pH=6.5; Kinetics; Reagent/catalyst; Temperature; Flow reactor;
D-Mannose
530-26-7

D-Mannose

sodium pyruvate
113-24-6

sodium pyruvate

(2S,4S,5R,6R)-2,4,5-Trihydroxy-6-((1R,2R)-1,2,3-trihydroxy-propyl)-tetrahydro-pyran-2-carboxylic acid
120104-31-6

(2S,4S,5R,6R)-2,4,5-Trihydroxy-6-((1R,2R)-1,2,3-trihydroxy-propyl)-tetrahydro-pyran-2-carboxylic acid

Conditions
ConditionsYield
With Neu5Ac aldolase for 24h;100%
With sodium azide; potassium phosphate buffer; diothiothreitol at 37℃; for 24h; N-acetylneuraminate pyruvate lyase;84%
With sodium azide; diothiothreitol; acylneuraminate pyruvate lyase covalently bound to 4percent agarose In water at 37℃; for 24h; 0.05 M potassium phosphate buffer, pH 7.2;84%
With DL-dithiothreitol at 37℃; for 72h; NeuAc aldolase, potassium phosphate buffer, pH 7.5;78%
With sodium azide; potassium phosphate buffer; acylneuraminate pyruvate lyase; agarose; diothiothreitol at 37℃; for 24h; Yield given;
sodium pyruvate
113-24-6

sodium pyruvate

L-alanin
56-41-7

L-alanin

Conditions
ConditionsYield
With sodium formate; ammonium chloride; NADH In aq. phosphate buffer at 25℃; for 6h; pH=8.0; Kinetics; Reagent/catalyst; Green chemistry; Enzymatic reaction;100%
With zinc(II) perchlorate; (R)-15-amino-methyl-14-hydroxy-5,5-dimethyl-2,8-dithia<9>(2,5)pyridinophane In methanol for 24h; Ambient temperature;72%
sodium pyruvate
113-24-6

sodium pyruvate

4-bromo-benzaldehyde
1122-91-4

4-bromo-benzaldehyde

(E)-4-(4-bromophenyl)-2-oxo-but-3-enoic acid
139005-22-4

(E)-4-(4-bromophenyl)-2-oxo-but-3-enoic acid

Conditions
ConditionsYield
With water; sodium hydroxide In ethanol at 20℃; for 1h; Knoevenagel Condensation; Inert atmosphere;100%
With potassium hydroxide In ethanol75%
Stage #1: sodium pyruvate; 4-bromo-benzaldehyde In methanol; water at 0℃; for 0.166667h; Inert atmosphere;
Stage #2: With potassium hydroxide In methanol; water at 0 - 20℃; Inert atmosphere;
Stage #3: With hydrogenchloride In methanol; water pH=2; Inert atmosphere;
With potassium hydroxide In ethanol; water at 0℃; for 3h;
Conditions
ConditionsYield
With Neisseria meningitidis CMP-sialic acid synthetase; Escherichia coli K12 sialic acid aldolase; Pasteurella multocida sialyl transferase; cytidine triphosphate; magnesium chloride pH=8.5; aq. Tris-HCl buffer; Enzymatic reaction;100%
N-(2-benzyloxyacetyl)-d-mannosamine

N-(2-benzyloxyacetyl)-d-mannosamine

sodium pyruvate
113-24-6

sodium pyruvate

N-(2-benzyloxyacetyl)-D-neuraminic acid

N-(2-benzyloxyacetyl)-D-neuraminic acid

Conditions
ConditionsYield
With Pasteurella multocida sialic acid aldolase In water at 37℃; for 48h; Enzymatic reaction; chemoselective reaction;100%
With sodium azide; sialic acid aldolase from Escherichia coli K1 In aq. phosphate buffer at 37℃; pH=7.6; Enzymatic reaction;63%
sodium pyruvate
113-24-6

sodium pyruvate

sodium lactate
312-85-6

sodium lactate

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In methanol at 25℃;100%
With [pentamethylcyclopentadienyl*Ir(N-phenyl-2-pyridinecarboxamidate)Cl]; sodium formate In methanol at 37℃; for 15h;100 %Spectr.
With cannabichromene; NADH; lactate dehydrogenase In aq. phosphate buffer Kinetics; Enzymatic reaction;
With tetrahydrocannabinolic acid; NADH; lactate dehydrogenase In aq. phosphate buffer Kinetics; Enzymatic reaction;
sodium pyruvate
113-24-6

sodium pyruvate

N-(N-benzyloxycarbonyl-glycyl)-D-mannosamine

N-(N-benzyloxycarbonyl-glycyl)-D-mannosamine

3-azidopropyl (β-O-D-galactopyranosyl)-(1→4)-O-β-D-glucopyranoside
229954-81-8

3-azidopropyl (β-O-D-galactopyranosyl)-(1→4)-O-β-D-glucopyranoside

3-azidopropyl O-[5-(N-benzyloxycarboxyamino)glycylamido-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosylonic acid]-(2->6)-O-β-D-galactopyranosyl-(1->4)-β-D-glucopyranoside

3-azidopropyl O-[5-(N-benzyloxycarboxyamino)glycylamido-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosylonic acid]-(2->6)-O-β-D-galactopyranosyl-(1->4)-β-D-glucopyranoside

Conditions
ConditionsYield
With E. coli sialic acid aldolase; N. meningitidis CMP-sialic acid synthetase; Photobacterium damsela α-2,6-sialyltransferase; cytidine triphosphate; magnesium chloride In water pH=8.8;99%
N-methoxyacetate-D-mannosamine

N-methoxyacetate-D-mannosamine

sodium pyruvate
113-24-6

sodium pyruvate

3-azidopropyl (β-O-D-galactopyranosyl)-(1→4)-O-β-D-glucopyranoside
229954-81-8

3-azidopropyl (β-O-D-galactopyranosyl)-(1→4)-O-β-D-glucopyranoside

3-azidopropyl O-(5-methoxyacetamido-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosylonic acid)-(2->6)-O-β-D-galactopyranosyl-(1->4)-β-D-glucopyranoside

3-azidopropyl O-(5-methoxyacetamido-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosylonic acid)-(2->6)-O-β-D-galactopyranosyl-(1->4)-β-D-glucopyranoside

Conditions
ConditionsYield
With E. coli sialic acid aldolase; N. meningitidis CMP-sialic acid synthetase; Photobacterium damsela α-2,6-sialyltransferase; cytidine triphosphate; magnesium chloride In water pH=8.8;99%
sodium pyruvate
113-24-6

sodium pyruvate

6-azido-6-deoxy-D-mannopyranose

6-azido-6-deoxy-D-mannopyranose

methyl β-D-galactopyranosyl-(1->4)-O-2-acetamido-2-deoxy-β-D-glucopyranoside acceptor substrate

methyl β-D-galactopyranosyl-(1->4)-O-2-acetamido-2-deoxy-β-D-glucopyranoside acceptor substrate

methyl sodium [9-azido-3,9-dideoxy-D-glycero-α-D-galacto-2-nonulo-pyranosyl]-onate-(2->3)-(β-D-galactopyranosyl)-(1->4)-O-2-acetamido-2-deoxy-β-D-glucopyranoside

methyl sodium [9-azido-3,9-dideoxy-D-glycero-α-D-galacto-2-nonulo-pyranosyl]-onate-(2->3)-(β-D-galactopyranosyl)-(1->4)-O-2-acetamido-2-deoxy-β-D-glucopyranoside

Conditions
ConditionsYield
Stage #1: sodium pyruvate; 6-azido-6-deoxy-D-mannopyranose With N. meningitidis ST3Gal-CMPNeu5Ac synthetase fusion protein; Neu5Ac-aldolase (Nal-311 (Toyobo); cytidine triphosphate In sodium hydroxide at 37℃; for 14h; pH=8.3 - 9.0; Enzymatic reaction;
Stage #2: methyl β-D-galactopyranosyl-(1->4)-O-2-acetamido-2-deoxy-β-D-glucopyranoside acceptor substrate With hydrogenchloride; recombinant sialyltransferase rat ST3Gal III; manganese(ll) chloride for 14h; pH=7.0; Enzymatic reaction; Further stages.;
98%
sodium pyruvate
113-24-6

sodium pyruvate

3-azidopropyl (β-O-D-galactopyranosyl)-(1→4)-O-β-D-glucopyranoside
229954-81-8

3-azidopropyl (β-O-D-galactopyranosyl)-(1→4)-O-β-D-glucopyranoside

3-azidopropyl O-(5-acetamido-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosylonic acid)-(2->6)-O-β-D-galactopyranosyl-(1->4)-β-D-glucopyranoside

3-azidopropyl O-(5-acetamido-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosylonic acid)-(2->6)-O-β-D-galactopyranosyl-(1->4)-β-D-glucopyranoside

Conditions
ConditionsYield
With E. coli sialic acid aldolase; N. meningitidis CMP-sialic acid synthetase; Photobacterium damsela α-2,6-sialyltransferase; cytidine triphosphate; magnesium chloride In water pH=8.8;98%
sodium pyruvate
113-24-6

sodium pyruvate

acetaldehyde
75-07-0

acetaldehyde

(R)-acetoin
53584-56-8

(R)-acetoin

Conditions
ConditionsYield
With thiamine diphosphate In phosphate buffer at 30℃; pH=6.0;98%
sodium pyruvate
113-24-6

sodium pyruvate

2-azido-2-deoxy-D-mannopyranose
97604-58-5

2-azido-2-deoxy-D-mannopyranose

(2S,3R,4S,5R,6R)-2-{[(2R,3S,4R,5R,6R)-4,5-dihydroxy-2-(hydroxymethyl)-6-(prop-2-yn-1-yloxy)tetrahydro-2H-pyran-3-yl]oxy}-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
857642-16-1

(2S,3R,4S,5R,6R)-2-{[(2R,3S,4R,5R,6R)-4,5-dihydroxy-2-(hydroxymethyl)-6-(prop-2-yn-1-yloxy)tetrahydro-2H-pyran-3-yl]oxy}-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

propargyl O-(5-azido-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosylonic acid)-(2->6)-O-β-D-galactopyranosyl-(1->4)-β-D-glucopyranoside
1196892-67-7

propargyl O-(5-azido-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosylonic acid)-(2->6)-O-β-D-galactopyranosyl-(1->4)-β-D-glucopyranoside

Conditions
ConditionsYield
With E. coli sialic acid aldolase; Photobacterium damsela α2,6-sialyltransferase; Neisseria meninigitidis CMP-sialic acid synthetase; cytidine-5’-triphosphate sodium salt; magnesium chloride at 20℃; for 15h; pH=8.5; aq. buffer; Enzymatic reaction;98%
sodium pyruvate
113-24-6

sodium pyruvate

1H-[1,2,4]triazole-3-carboxylic acid hydrazide
21732-98-9

1H-[1,2,4]triazole-3-carboxylic acid hydrazide

C6H6N5O3(1-)*Na(1+)
1353017-20-5

C6H6N5O3(1-)*Na(1+)

Conditions
ConditionsYield
In methanol for 24h; Reflux;98%
6-deoxy-6-fluoro-D-mannopyranose

6-deoxy-6-fluoro-D-mannopyranose

sodium pyruvate
113-24-6

sodium pyruvate

4-nitrophenyl-β-D-galactopyranoside
3150-24-1

4-nitrophenyl-β-D-galactopyranoside

C21H27FNO15(1-)*Na(1+)

C21H27FNO15(1-)*Na(1+)

Conditions
ConditionsYield
With Neisseria meningitidis CMP-sialic acid synthetase; cytidine 5′-triphosphate disodium salt; Pasteurella multocida sialic acid aldolase; Photobacterium damselae α2-6-sialyltransferase; magnesium chloride pH=8.5; aq. buffer; Enzymatic reaction;98%
2,6-dideoxy-2-glycolylamino-6-fluoro-D-mannopyranose

2,6-dideoxy-2-glycolylamino-6-fluoro-D-mannopyranose

sodium pyruvate
113-24-6

sodium pyruvate

4-nitrophenyl-β-D-galactopyranoside
3150-24-1

4-nitrophenyl-β-D-galactopyranoside

C23H30FN2O16(1-)*Na(1+)

C23H30FN2O16(1-)*Na(1+)

Conditions
ConditionsYield
With Neisseria meningitidis CMP-sialic acid synthetase; cytidine 5′-triphosphate disodium salt; Pasteurella multocida sialic acid aldolase; Pasteurella multocida multifunctional α2-3-sialyltransferase; magnesium chloride pH=8.5; aq. buffer; Enzymatic reaction;98%
sodium pyruvate
113-24-6

sodium pyruvate

2-acetamido-2,6-dideoxy-6-fluoro-D-mannopyranose
74950-73-5, 74950-79-1, 77870-49-6

2-acetamido-2,6-dideoxy-6-fluoro-D-mannopyranose

4-nitrophenyl-β-D-galactopyranoside
3150-24-1

4-nitrophenyl-β-D-galactopyranoside

C23H30FN2O15(1-)*Na(1+)

C23H30FN2O15(1-)*Na(1+)

Conditions
ConditionsYield
With Neisseria meningitidis CMP-sialic acid synthetase; cytidine 5′-triphosphate disodium salt; Pasteurella multocida sialic acid aldolase; Pasteurella multocida multifunctional α2-3-sialyltransferase; magnesium chloride pH=8.5; aq. buffer; Enzymatic reaction;98%
sodium pyruvate
113-24-6

sodium pyruvate

2-acetamido-2,4-dideoxy-4-fluoro-D-mannopyranoside

2-acetamido-2,4-dideoxy-4-fluoro-D-mannopyranoside

4-nitrophenyl-β-D-galactopyranoside
3150-24-1

4-nitrophenyl-β-D-galactopyranoside

A

4-nitrophenyl O-(7-fluoro-5-acetamido-3,5,7-trideoxy-D-glycero-α-D-galacto-2-nonulopyranosylonic acid)-(2→3)-O-β-D-galactopyranoside

4-nitrophenyl O-(7-fluoro-5-acetamido-3,5,7-trideoxy-D-glycero-α-D-galacto-2-nonulopyranosylonic acid)-(2→3)-O-β-D-galactopyranoside

B

4-nitrophenyl O-(7-fluoro-5-acetamido-3,5,7-trideoxy-D-glycero-α-D-galacto-2-nonulopyranosylonic acid)-(2→6)-O-β-D-galactopyranoside

4-nitrophenyl O-(7-fluoro-5-acetamido-3,5,7-trideoxy-D-glycero-α-D-galacto-2-nonulopyranosylonic acid)-(2→6)-O-β-D-galactopyranoside

Conditions
ConditionsYield
With cytidine 5′-triphosphate disodium salt; neisseria meningitides CMP-sialicacid synthetase; pasteurella multocida sialic acidaldolase; magnesium chloride In aq. buffer at 37℃; Inert atmosphere; Enzymatic reaction;A 98%
B 92%
4-deoxy-4-fluoro-D-mannopyranoside

4-deoxy-4-fluoro-D-mannopyranoside

sodium pyruvate
113-24-6

sodium pyruvate

4-nitrophenyl-β-D-galactopyranoside
3150-24-1

4-nitrophenyl-β-D-galactopyranoside

A

4-nitrophenyl O-(3,7-dideoxy-7-fluoro-D-glycero-α-D-galacto-2-nonulopyranosylonic acid)-(2→3)-O-β-D-galactopyranoside

4-nitrophenyl O-(3,7-dideoxy-7-fluoro-D-glycero-α-D-galacto-2-nonulopyranosylonic acid)-(2→3)-O-β-D-galactopyranoside

B

4-nitrophenyl O-(3,9-dideoxy-7-fluoro-D-glycero-α-D-galacto-2-nonulopyranosylonic acid)-(2→6)-O-β-D-galactopyranoside

4-nitrophenyl O-(3,9-dideoxy-7-fluoro-D-glycero-α-D-galacto-2-nonulopyranosylonic acid)-(2→6)-O-β-D-galactopyranoside

Conditions
ConditionsYield
With cytidine 5′-triphosphate disodium salt; neisseria meningitides CMP-sialicacid synthetase; pasteurella multocida sialic acidaldolase; magnesium chloride In aq. buffer at 37℃; Inert atmosphere; Enzymatic reaction;A 98%
B 95%
sodium pyruvate
113-24-6

sodium pyruvate

2-acetamido-4-azido-2,4-dideoxy-D-mannopyranoside

2-acetamido-4-azido-2,4-dideoxy-D-mannopyranoside

4-nitrophenyl-β-D-galactopyranoside
3150-24-1

4-nitrophenyl-β-D-galactopyranoside

A

4-nitrophenyl O-(7-azido-5-acetamido-3,5,7-trideoxy-D-glycero-α-D-galacto-2-nonulopyranosylonic acid)-(2→6)-O-β-D-galactopyranoside

4-nitrophenyl O-(7-azido-5-acetamido-3,5,7-trideoxy-D-glycero-α-D-galacto-2-nonulopyranosylonic acid)-(2→6)-O-β-D-galactopyranoside

B

C23H30N5O15(1-)

C23H30N5O15(1-)

Conditions
ConditionsYield
With cytidine 5′-triphosphate disodium salt; neisseria meningitides CMP-sialicacid synthetase; pasteurella multocida sialic acidaldolase; magnesium chloride In aq. buffer at 37℃; Inert atmosphere; Enzymatic reaction;A 98%
B 80%
sodium pyruvate
113-24-6

sodium pyruvate

4-nitrophenyl-β-D-galactopyranoside
3150-24-1

4-nitrophenyl-β-D-galactopyranoside

4-azido-4-deoxy-D-mannopyranoside

4-azido-4-deoxy-D-mannopyranoside

A

4-nitrophenyl O-(7-azido-3,7-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosylonic acid)-(2→3)-O-β-D-galactopyranoside

4-nitrophenyl O-(7-azido-3,7-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosylonic acid)-(2→3)-O-β-D-galactopyranoside

B

4-nitrophenyl O-(7-azido-3,7-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosylonic acid)-(2→6)-O-β-D-galactopyranoside

4-nitrophenyl O-(7-azido-3,7-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosylonic acid)-(2→6)-O-β-D-galactopyranoside

Conditions
ConditionsYield
With cytidine 5′-triphosphate disodium salt; neisseria meningitides CMP-sialicacid synthetase; pasteurella multocida sialic acidaldolase; magnesium chloride In aq. buffer at 37℃; Inert atmosphere; Enzymatic reaction;A 98%
B 89%
2,6-diacetamido-2,6-dideoxy-D-mannopyranose
19949-68-9, 37077-16-0, 60135-21-9

2,6-diacetamido-2,6-dideoxy-D-mannopyranose

3-azidopropyl β-D-galactopyranosyl-(1->3)-2-acetamido-2-deoxy-α-D-galactopyranoside
1257307-68-8

3-azidopropyl β-D-galactopyranosyl-(1->3)-2-acetamido-2-deoxy-α-D-galactopyranoside

sodium pyruvate
113-24-6

sodium pyruvate

3-azidopropyl O-(5,9-diacetamido-3,5,9-trideoxy-D-glycero-α-D-galacto-2-nonulopyranosylonic acid)-(2→6)-O-β-D-galactopyranosyl-(1→3)-2-acetamido-2-deoxy-α-D-galactopyranoside

3-azidopropyl O-(5,9-diacetamido-3,5,9-trideoxy-D-glycero-α-D-galacto-2-nonulopyranosylonic acid)-(2→6)-O-β-D-galactopyranosyl-(1→3)-2-acetamido-2-deoxy-α-D-galactopyranoside

Conditions
ConditionsYield
With CTP(3Na+); Neisseria meningitidis CMP-sialic acid synthetase; pasteurella multocida sialic acidaldolase; Photobacterium damselae α2-6 sialyltransferase; magnesium chloride In aq. buffer at 37℃; pH=7.5; Enzymatic reaction;98%
4-nitrophenyl β-D-galactopyranosyl-(1→4)-β-D-glucopyranoside
4419-94-7

4-nitrophenyl β-D-galactopyranosyl-(1→4)-β-D-glucopyranoside

sodium pyruvate
113-24-6

sodium pyruvate

4-nitrophenyl O-(5-acetamido-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosylonicacid)-(2→3)-O-β-D-galactopyranosyl-(1→4)-β-D-glucopyranoside

4-nitrophenyl O-(5-acetamido-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosylonicacid)-(2→3)-O-β-D-galactopyranosyl-(1→4)-β-D-glucopyranoside

Conditions
ConditionsYield
Stage #1: N-Acetyl-D-glucosamine; sodium pyruvate With Escherichia coli. ΔnanTEK/pNA; magnesium chloride In aq. buffer at 30℃; for 16h; Enzymatic reaction;
Stage #2: 4-nitrophenyl β-D-galactopyranosyl-(1→4)-β-D-glucopyranoside With cytidine 5’-monophosphate-Sia synthetase; sialyltransferase Pm2,3ST; cytidine triphosphate at 25℃; for 2h;
98%
4-nitrophenyl β-D-galactopyranosyl-(1→4)-β-D-glucopyranoside
4419-94-7

4-nitrophenyl β-D-galactopyranosyl-(1→4)-β-D-glucopyranoside

sodium pyruvate
113-24-6

sodium pyruvate

4-nitrophenyl O-(5-acetamido-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosylonicacid)-(2→6)-O-β-D-galactopyranosyl-(1→4)-β-D-glucopyranoside

4-nitrophenyl O-(5-acetamido-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosylonicacid)-(2→6)-O-β-D-galactopyranosyl-(1→4)-β-D-glucopyranoside

Conditions
ConditionsYield
Stage #1: N-Acetyl-D-glucosamine; sodium pyruvate With Escherichia coli. ΔnanTEK/pNA; magnesium chloride In aq. buffer at 30℃; for 16h; Enzymatic reaction;
Stage #2: 4-nitrophenyl β-D-galactopyranosyl-(1→4)-β-D-glucopyranoside With cytidine 5’-monophosphate-Sia synthetase; sialyltransferase Pd2,6ST; cytidine triphosphate at 25℃; for 2h;
98%
p-methylphenyl-1-thio-β-D-galactopyranoside
1152-39-2, 28244-98-6, 121523-95-3, 131488-68-1

p-methylphenyl-1-thio-β-D-galactopyranoside

2,4-diazido-2,4,6-trideoxy-D-mannose

2,4-diazido-2,4,6-trideoxy-D-mannose

sodium pyruvate
113-24-6

sodium pyruvate

C22H29N6O10S(1-)

C22H29N6O10S(1-)

Conditions
ConditionsYield
With Neisseria meningitidis CMP-sialic acid synthetase; Pasteurella multocida sialic acid aldolase; Pasteurella multocida sialyltransferase 1 M144D mutant; cytidine triphosphate; magnesium chloride In water at 30℃; for 48h; Reagent/catalyst; Enzymatic reaction;98%
p-methylphenyl-1-thio-β-D-galactopyranoside
1152-39-2, 28244-98-6, 121523-95-3, 131488-68-1

p-methylphenyl-1-thio-β-D-galactopyranoside

2,4-diazido-2,4,6-trideoxy-D-mannose

2,4-diazido-2,4,6-trideoxy-D-mannose

sodium pyruvate
113-24-6

sodium pyruvate

C22H30N6O10S

C22H30N6O10S

Conditions
ConditionsYield
With Neisseria meningitidis CMP-sialic acid synthetase; Pasteurella multocida sialic acid aldolase; pasteurella multocida 2-3-sialyltransferase 1 M144D mutant; cytidine triphosphate; magnesium chloride In water at 30℃; for 48h; pH=8.5; Enzymatic reaction;98%
sodium pyruvate
113-24-6

sodium pyruvate

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

potassium (E)-4-(4-methoxyphenyl)-2-oxobut-3-enoate

potassium (E)-4-(4-methoxyphenyl)-2-oxobut-3-enoate

Conditions
ConditionsYield
With potassium hydroxide In methanol at 0 - 25℃;98%
D-Mannose
530-26-7

D-Mannose

sodium pyruvate
113-24-6

sodium pyruvate

3-azidopropyl (β-O-D-galactopyranosyl)-(1→4)-O-β-D-glucopyranoside
229954-81-8

3-azidopropyl (β-O-D-galactopyranosyl)-(1→4)-O-β-D-glucopyranoside

3-azidopropyl O-(3-deoxy-D-glycero-α-D-galacto-2-nonulopyranosylonic acid)-(2->6)-O-β-D-galactopyranosyl-(1->4)-β-D-glucopyranoside

3-azidopropyl O-(3-deoxy-D-glycero-α-D-galacto-2-nonulopyranosylonic acid)-(2->6)-O-β-D-galactopyranosyl-(1->4)-β-D-glucopyranoside

Conditions
ConditionsYield
With E. coli sialic acid aldolase; N. meningitidis CMP-sialic acid synthetase; Photobacterium damsela α-2,6-sialyltransferase; cytidine triphosphate; magnesium chloride In water pH=8.8;97%
N-methoxyacetate-D-mannosamine

N-methoxyacetate-D-mannosamine

sodium pyruvate
113-24-6

sodium pyruvate

4-nitrophenyl-β-D-galactopyranoside
3150-24-1

4-nitrophenyl-β-D-galactopyranoside

4-nitrophenyl O-[5-(2-methoxyacetamido)-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosylonic acid]-(2->6)-O-β-D-galactopyranoside

4-nitrophenyl O-[5-(2-methoxyacetamido)-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosylonic acid]-(2->6)-O-β-D-galactopyranoside

Conditions
ConditionsYield
With Neisseria meningitidis CMP-sialic acid synthetase; Pasturella multocida sialic acid aldolase; Photobacterium damsela α2-6-sialyltransferase; magnesium chloride; cytidine 5'-triphosphate disodium salt In water at 37℃; pH=8.8; aq. Tris-HCl buffer; Enzymatic reaction;97%
sodium pyruvate
113-24-6

sodium pyruvate

5-Bromo-1H-indole-2,3-dione
87-48-9

5-Bromo-1H-indole-2,3-dione

6-bromoquinoline-2 ,4-dicarboxylic acid
250641-14-6

6-bromoquinoline-2 ,4-dicarboxylic acid

Conditions
ConditionsYield
With sodium hydroxide In water for 4h; Reflux; Inert atmosphere;97%
With water; sodium hydroxide at 110℃; under 4500.45 Torr; for 0.166667h; Microwave irradiation;92%
With sodium hydroxide In water at 110℃; under 3750.38 Torr; for 0.333333h; Microwave irradiation;81.1%

113-24-6Related news

ORIGINAL ARTICLESynthesis, characterization and thermal properties of Sodium pyruvate (cas 113-24-6) thiosemicarbazone and some of its metal complexes08/24/2019

The Schiff base sodium pyruvate thiosemicarbazone (SPTSC) was synthesized from the condensation of sodium pyruvate and thiosemicarbazide hydrochloride in aqueous medium. This molecule coordinates to a variety of divalent metal ions M2+ (M = Fe, Co, Ni, Cu or Cd) and one type of complexes was obt...detailed

Circulating tricarboxylic acid cycle metabolite levels in citrin-deficient children with metabolic adaptation, with and without Sodium pyruvate (cas 113-24-6) treatment08/23/2019

Citrin deficiency causes adult-onset type II citrullinemia (CTLN-2), which later manifests as severe liver steatosis and life-threatening encephalopathy. Long-standing energy deficit of the liver and brain may predispose ones to CTLN-2. Here, we compared the energy-driving tricarboxylic acid (TC...detailed

Non-damaging stretching combined with Sodium pyruvate (cas 113-24-6) supplement accelerate migration of fibroblasts and myoblasts during gap closure08/22/2019

BackgroundSustained, low- and mid-level (3–6%), radial stretching combined with varying concentrations of sodium pyruvate (NaPy) supplement increase the migration rate during microscale gap closure following an in vitro injury; NaPy is a physiological supplement often used in cell-culture media...detailed

Biomarkers and clinical rating scales for Sodium pyruvate (cas 113-24-6) therapy in patients with mitochondrial disease08/21/2019

Biomarkers and two clinical rating scales—the Japanese mitochondrial disease-rating scale (JMDRS) and Newcastle mitochondrial disease adult scale (NMDAS)—are clinically used when treating patients with mitochondrial disease. We explored the biomarker(s) and clinical rating scale(s) that are ap...detailed

113-24-6Relevant articles and documents

Chemical transformations of the condensation products of pyridoxal with L-α-alanine and D-α-alanine

Pishchugin,Tuleberdiev

, p. 117 - 120 (2009)

The kinetics and mechanism of the reactions of pyridoxal with L- and D-α-alanine were studied. Under comparable conditions, the condensation of L- and D-α-alanines with pyridoxal includes three kinetically different steps. The first fast step is addition

-

Price,Levintow

, p. 22 (1952)

-

Alcohol oxidation catalysed by Ru(VI) in the presence of alkaline hexacyanoferrate(III)

Poblete, Francisco J.,Corrochano, Pablo

, p. 1088 - 1092 (2010)

The oxidation of sodium lactate, 2-methyl-2,4-pentanediol, 2,4-butanediol, 2-butanol and 2-propanol upon treatment with alkaline hexacyanoferrate(III) using a Ru(VI) catalyst is highly effective for the oxidation of alcohols by Fe(CN)63-. The reaction mechanism proposed involves the oxidation of the alcohol by the catalyst, a process that occurs through the formation of a substrate-catalyst complex. The decomposition of this complex yields Ru(IV) and a carbocation (owing to a hydride transfer from the α-C-H bond of the alcohol to the oxoligand of ruthenium). The role of the co-oxidant, hexacyanoferrate(III), is to regenerate the catalyst. In the oxidation reactions, the rate constants for complex decomposition and catalyst regeneration have been determined and a comparative study of the structure versus reactivity has been carried out. Copyright

Preparation method of sodium pyruvate

-

Paragraph 0033-0122, (2018/07/30)

The invention relates to the field of preparation of sodium pyruvate, in particular to a preparation method of sodium pyruvate. The preparation method comprises the following steps that ethyl lactateis subjected to an oxidizing reaction under existing of a catalyst, and sodium pyruvate is obtained after hydrolyzation and neutralization are conducted, wherein the catalyst is one or more of 2,2,6,6-tetramethylpiperidine oxide, 9-azabicyclo[3.3.1]nonane-N-oxy-compound, 9-azabicyclo[3.3.1]nonane-3-ene-N-oxy-compound, 4,2,2,6,6-tetrametylpiperidine oxide and 4-amino-2,2,6,6-tetrametylpiperidine oxide. Compared with the existing commonly used bromine, the prepared method of sodium pyruvate improves the reaction rate of oxidization, and in the oxidization reaction process, the reaction is more steady and safer. In addition, a by-product, namely yellow oily matter is reduced, and post-treatment is easier as well.

Rational design of stereoselectivity in the class II pyruvate aldolase BphI

Baker, Perrin,Seah, Stephen Y. K.

scheme or table, p. 507 - 513 (2012/03/07)

BphI, a pyruvate-specific class II aldolase, catalyzes the reversible carbon-carbon bond formation of 4-hydroxy-2-oxoacids up to eight carbons in length. During the aldol addition catalyzed by BphI, the S-configured stereogenic center at C4 is created via attack of a pyruvate enolate intermediate on the si face of the aldehyde carbonyl of acetaldehyde to form 4(S)-hydroxy-2-oxopentanoate. Replacement of a Leu-87 residue within the active site of the enzyme with polar asparagine and bulky tryptophan led to enzymes with no detectable aldolase activity. These variants retained decarboxylase activity for the smaller oxaloacetate substrate, which is not inhibited by excess 4-hydroxy-2-oxopentanoate, confirming the results from molecular modeling that Leu-87 interacts with the C4-methyl of 4(S)-hydroxy-2-oxoacids. Double variants L87N;Y290F and L87W;Y290F were constructed to enable the binding of 4(R)-hydroxy-2-oxoacids by relieving the steric hindrance between the 5-methyl group of these compounds and the hydroxyl substituent on the phenyl ring of Tyr-290. The resultant enzymes were shown to exclusively utilize only 4(R)- and not 4(S)-hydroxy-2-oxopentanoate as the substrate. Polarimetric analysis confirmed that the double variants are able to synthesize 4-hydroxy-2-oxoacids up to eight carbons in length, which were the opposite stereoisomer compared to those produced by the wild-type enzyme. Overall the kcat/K m values for pyruvate and aldehydes in the aldol addition reactions were affected 10-fold in the double variants relative to the wild-type enzyme. Thus, stereocomplementary class II pyruvate aldolases are now available to create chiral 4-hydroxy-2-oxoacid skeletons as synthons for organic reactions.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 113-24-6