Solid phase synthesis of peptidoglycan monomers for the generation of a combinatorial library

Article abstract of DOI:10.1016/0040-4039(96)01849-7

Solid phase synthesis of peptidoglycan monomers was conducted by coupling the corresponding lipid-bearing glycocarboxylic acids to resin-bound peptides. The efficiency of coupling reagents was found to be in descending order of HATU > HBTU > PyBOP > EEDQ. There was no obvious difference in coupling yield between conducting the solid phase synthesis on polystyrene resins or on polyethylene glycol grafted polystyrene resins.