The Synthesis of Conformationally Constrained Peptides and Pseudo-Peptides Incorporating an Endo-(2S, 3R)-2-Amino-3-Carboxy-Norborn-5-ene Residue

Article abstract of DOI:10.1055/s-1997-706

Methodology has been developed to carry out a Curtius rearrangement on enantiomerically pure amido-acids derived from (S)-proline esters The resulting isocyanates were used to prepare conformationally constrained peptides incorporating an endo-(2S, 3R)-2-amino-3-carboxy-norborn-5-ene residue.