Zeolite-catalyzed acylation of heterocyclic compounds - VI. One-step synthesis of 3-(benzofuran-2-carbonyl)pentane-2,4-dione from 2- acetylbenzofuran over HY-zeolite

Article abstract of DOI:10.1016/S0040-4020(98)00904-1

The reaction between 2-acetylbenzofuran and acetic anhydride at 60°C in the presence of HY-zeolite (Si/Al = 16) led to a single final product:3- (benzofuran-2-carbonyl)pentane-2,4-dione resulting from two consecutive acylation steps on the side chain. It was obtained in a 90% purity at around 50% conversion of 2-acetylbenzofuran. Other minor products and intermediates were also identified. A mechanism is proposed to account for the formation of the various products.