Synthesis and cytotoxic evaluation of cycloheximide derivatives as potential inhibitors of FKBP12 with neuroregenerative properties

Article abstract of DOI:10.1021/jm991038t

On the basis of the new finding that the protein synthesis inhibitor cycloheximide (1, 4-[2-(3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]-2,6- piperidinedione) is able to competitively inhibit hFKBP12 (K₁ = 3.4 μM) and homologous enzymes, a se