Bioorganic and Medicinal Chemistry Letters p. 1729 - 1731 (2000)
Update date:2022-07-31
Topics:
Patel, Mona
McHugh Jr., Robert J.
Cordova, Beverly C.
Klabe, Ronald M.
Erickson-Viitanen, Susan
Trainor, George L.
Rodgers, James D.
A series of 3,3-disubstituted quinoxalinones was prepared and evaluated as HIV-1 reverse transcriptase inhibitors. The N-allyl (6b and 6f), N-cyclopropylmethyl (6a, 6g, 6h and 6k) and N-carboalkoxy (6m-6y) substituted compounds displayed activity comparable or better than Efavirenz and GW420867X. (C) 2000 Dupont Pharmaceuticals Company. Published by Elsevier Science Ltd. All rights reserved.
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