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Folic acid 59-30-3 TOP supplier in China
Cas No: 59-30-3
USD $ 11.0-12.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
high quality Vitamin B9 Folic Acid Powder
Cas No: 59-30-3
No Data 1 Kilogram 10000 Kilogram/Quarter Xi'an Harmonious Natural Bio-Technology Co., Ltd. Contact Supplier
Manufacture Folic Acid USP/BP/FCC with competitive price
Cas No: 59-30-3
No Data 25 Kilogram 5 Metric Ton/Month Hangzhou Think Chemical Co. Ltd Contact Supplier
Folic acid 59-30-3
Cas No: 59-30-3
USD $ 10.0-10.0 / Kilogram 1 Kilogram 10000 Kilogram/Month HANWAYS CHEMPHARM CO.,LIMITED Contact Supplier
Bulk Powder Vitamin B9 Folic acid
Cas No: 59-30-3
USD $ 110.0-110.0 / Kilogram 1 Kilogram 10 Metric Ton/Month Shaanxi Greenyo Biotech Co., Ltd. Contact Supplier
Folic acid/CAS:59-30-3/Vitamin B; Vitamin B11
Cas No: 59-30-3
USD $ 2.0-5.0 / Metric Ton 100 Metric Ton 10000 Metric Ton/Day Hubei DiBo chemical co., LTD Contact Supplier
Folic acid
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USD $ 110.0-120.0 / Kilogram 1 Kilogram 1 Kilogram/Day DB BIOTECH CO., LTD Contact Supplier
Folic Acid
Cas No: 59-30-3
USD $ 6.0-6.0 / Kilogram 1 Kilogram 1000 Kilogram/Month Purestar Chem Enterprise Co.,Ltd Contact Supplier
Folic Acid (Vitamin B9)
Cas No: 59-30-3
No Data 1 Kilogram 10-20 Metric Ton/Month EnBridge PharmTech Co., Ltd. Contact Supplier
Best Price/Factory price Folic acid CAS:59-30-3 CAS NO.59-30-3
Cas No: 59-30-3
No Data 1 Kilogram 10000 Metric Ton/Month Jilin haofei import and export trade Co.,Ltd Contact Supplier

59-30-3 Usage

Air & Water Reactions

Insoluble in water. Aqueous solutions have pHs of 4.0-4.8.

Purification Methods

If paper chromatography indicates impurities, then recrystallise it from hot H2O or from dilute acid [Walker et al. J Am Chem Soc 70 19 1948]. Impurities may be removed by repeated extraction with n-BuOH of a neutral aqueous solution of folic acid (by suspending in H2O and adding N NaOH dropwise till the solid dissolves, then adjusting the pH to ~7.0-7.5) followed by precipitation with acid, filtration, or better collected by centrifugation and recrystallised form hot H2O. [Blakley Biochem J 65 331 1975, Kalifa et al. Helv Chim Acta 6 1 2739 1978.] Chromatography on cellulose followed by filtration through charcoal has also been used to obtain pure acid. [Sakami & Knowles Science 129 274 1959.] UV: max 247 and 296nm ( 12,800 and 18,700) in H2O pH 1.0; 282 and 346nm ( 27.600 and 7,200) in H2O pH 7.0; 256, 284 and 366nm ( 24600, 24,500 and 86,00) in H2O pH 13 [Rabinowitz in The Enzymes (Boyer et al. Eds), 2 185 1960]. [Beilstein 26 III/IV 3944.]

Reactivity Profile

Acid solutions of Folic acid are sensitive to heat, but towards neutrality, stability progressively increases. Solutions are inactivated by ultraviolet light and alkaline solutions are sensitive to oxidation. Folic acid is also inactivated by light. Folic acid is incompatible with oxidizing agents, reducing agents and heavy metal ions.

Occurrence

Synthetic

Safety Profile

Poison by intraperitoneal and intravenous routes. Experimental teratogenic effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

Fire Hazard

Flash point data for Folic acid are not available; however, Folic acid is probably combustible.

Originator

Folvite, Lederle, US ,1946

Veterinary Drugs and Treatments

Folic acid is used to treat folic acid deficiency in dogs, cats, and horses (theoretically in other animal species as well) often due to small intestinal disease. Cats with exocrine pancreatic insufficiency appear to be most at risk for folate and cobalamin deficiencies secondary to malabsorption of folic acid in the diet. Dogs with exocrine pancreatic insufficiency often are noted to have increased folate levels secondary to overgrowths of folate-synthesizing bacteria in the proximal small intestine. Chronic administration of dihydrofolate reductase inhibiting drugs such as pyrimethamine, ormetoprim or trimethoprim can potentially lead to reduced activated folic acid (tetrahydrofolic acid); folic acid supplementation is sometimes prescribed in an attempt to alleviate this situation.

Uses

Folic Acid is a water-soluble b-complex vitamin that aids in the for- mation of red blood cells, prevents certain anemias, and is essential in normal metabolism. high-temperature processing affects its sta- bility. it is best stored at lower than room temperatures. it is also termed folacin. it is found in liver, nuts, and green vegetables.

Chemical Properties

orange to yellow crystalline powder

Manufacturing Process

The following description is taken from US Patent 2,956,057. 100 grams of 1,3,3-trichloroacetone are heated on a boiling water bath and 95 grams of bromine are added thereto in drops while being stirred and the stirring is continued for about 1 hour. The resulting reaction solution is distilled under reduced pressure. 115 grams of 1-bromo-1,3,3- trichloroacetone are obtained having a boiling point of 85° to 95°C/17 mm (Hg). For the preparation of the hydrate, 100 grams of water are added to 100 grams of 1bromo-1,3,3-trichloroacetone, which is agitated and cooled. A white scaly crystal of hydrate of 1-bromo-1,3,3-trichloroacetone is obtained (100 grams), having a melting point of 52° to 53°C. 8.9 grams of 2,4,5-triamino-6-hydroxypyrimidine hydrochloride and 8 grams of p-aminobenzoylglutamic acid are dissolved in 400 cc warm water, which is cooled at 35° to 27°C and adjusted to pH 4 by using 20% caustic soda solution. To this solution was simultaneously added dropwise a solution obtained by dissolving 13.4 grams of 1-bromo-1,3,3-trichloroacetone hydrate in 90 cc of 50% methanol and 24 grams of 35% aqueous sodium bisulfite solution over a period of approximately 2 hours. During this period, in order to maintain the pH value of the reaction solution at 4 to 5, 20% caustic soda solution is added from time to time. The precipitate, formed by stirring for 5 hours after dropping was finished, is filtered, and the filtrated precipitate is refined; 5.6 grams of pure pteroylglutamic acid is obtained.

Uses

hematopoietic vitamin

Therapeutic Function

Treatment of B vitamin (folacin) deficiency

General Description

Odorless orange-yellow needles or platelets. Darkens and chars from approximately 482°F.

Uses

folic acid is generally used as an emollient. In vitro and in vivo skin studies now indicate its capacity to aid in DnA synthesis and repair, promote cellular turnover, reduce wrinkles, and promote skin firmness. There is some indication that folic acid may also protect DnA from uV-induced damage. Folic acid is a member of the vitamin B complex and is naturally occurring in leafy greens.

Uses

A vitamin needed to synthesize DNA, conduct DNA repair and methylate DNA, it also acts as a cofactor in biological reactions involving folate.

Uses

Literature tends to indicate that B vitamins cannot pass through the layers of the skin and, therefore, are of no value in the skin surface. Current experiments demonstrate, however, that vitamin B2 acts as a chemical reaction accelerator, enhancing the performance of tyrosine derivatives in suntan-accelerating preparations.

Definition

ChEBI: An N-acyl-amino acid that is a form of the water-soluble vitamin B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation.

Description

Folic acid (folate) is a kind of B-vitamin which is mainly present in the liver and kidney. It has various kinds of pharmacological and physiological effects. It is involved in amino acid metabolism, purine and pyrimidine synthesis, and is also essential for hematopoiesis and red blood cell generation. In women pregnancy, folate can effectively prevent neural tube defects in the baby. It plays important role in fertility through contributing to spermatogenesis. It can also reduce the incidence of heart disease, stroke and cancer.? Folate deficiency may lead to various kinds of diseases including glossitis, diarrhea, depression, confusion, anemia, and fetal neural tube defectsand brain defects (during pregnancy). Other symptoms may include fatigue, gray hair, mouth sores, poor growth, and swollen tongue.
InChI:InChI=1/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/p-2/t12-/m1/s1

59-30-3 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
TCI America (F0043)  Folic Acid Hydrate  >98.0%(HPLC)(T) 59-30-3 25g 475.00CNY Detail
Sigma-Aldrich (PHR1035)  Folicacid  pharmaceutical secondary standard; traceable to USP and PhEur 59-30-3 PHR1035-1G 732.19CNY Detail
Sigma-Aldrich (F0300000)  Folicacid  European Pharmacopoeia (EP) Reference Standard 59-30-3 F0300000-2EA 1,880.19CNY Detail
USP (1286005)  Folicacid  United States Pharmacopeia (USP) Reference Standard 59-30-3 1286005-500MG 4,662.45CNY Detail
Supelco (47866)  Folicacid  analytical standard 59-30-3 000000000000047866 300.69CNY Detail
Sigma-Aldrich (F8798)  Folicacid  meets USP testing specifications 59-30-3 F8798-5G 424.71CNY Detail
Sigma-Aldrich (F8798)  Folicacid  meets USP testing specifications 59-30-3 F8798-25G 1,413.36CNY Detail
Sigma-Aldrich (F8798)  Folicacid  meets USP testing specifications 59-30-3 F8798-100G 5,270.85CNY Detail

59-30-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name folic acid

1.2 Other means of identification

Product number -
Other names pteroic acid-glutamate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:59-30-3 SDS

59-30-3Synthetic route

N-(4-aminobenzoyl)-L-glutamic acid
4271-30-1

N-(4-aminobenzoyl)-L-glutamic acid

2,5,6-triamino-1,4-dihydropyrimidin-4-one hydrochloride

2,5,6-triamino-1,4-dihydropyrimidin-4-one hydrochloride

folate
59-30-3

folate

Conditions
ConditionsYield
With 1,1,1-trichloroacetone; sodium sulfite In water at 40 - 50℃; for 1h; pH=3 - 4; pH-value; Temperature;85%
1,1,3-trichloroacetone
921-03-9

1,1,3-trichloroacetone

N-(4-aminobenzoyl)-L-glutamic acid
4271-30-1

N-(4-aminobenzoyl)-L-glutamic acid

2,4,5-triamino-6-hydroxypyrimidine sulfate
35011-47-3

2,4,5-triamino-6-hydroxypyrimidine sulfate

folate
59-30-3

folate

Conditions
ConditionsYield
With sodium metabisulfite at 20 - 30℃; for 2h; Temperature; Ionic liquid;83.2%
With sodium metabisulfite; sodium acetate at 45℃; for 3h; Temperature;46.2%
1,1,1-trichloroacetone
918-00-3

1,1,1-trichloroacetone

p-Nitrobenzoyl-L-(+)-glutamic acid
6758-40-3

p-Nitrobenzoyl-L-(+)-glutamic acid

2,4-diamino-5-nitroso-6-hydroxypyrimidine
2387-48-6

2,4-diamino-5-nitroso-6-hydroxypyrimidine

folate
59-30-3

folate

Conditions
ConditionsYield
Stage #1: p-Nitrobenzoyl-L-(+)-glutamic acid; 2,4-diamino6-hydroxy-5-nitroso pyrimidine With hydrogen In water at 82℃; under 6000.6 Torr;
Stage #2: 1,1,1-trichloroacetone With sodium metabisulfite; sodium hydroxide In water at 45℃; pH=4.5; pH-value; Pressure; Temperature;
80%
1,1,1-trichloroacetone
918-00-3

1,1,1-trichloroacetone

N-(4-aminobenzoyl)-L-glutamic acid
4271-30-1

N-(4-aminobenzoyl)-L-glutamic acid

2,4,5-triamino-6-hydroxypyrimidine sulfate
35011-47-3

2,4,5-triamino-6-hydroxypyrimidine sulfate

folate
59-30-3

folate

Conditions
ConditionsYield
Stage #1: 1,1,1-trichloroacetone; N-(4-aminobenzoyl)-L-glutamic acid With sodium acetate; sodium sulfite In acetic acid at 43℃; for 0.5h;
Stage #2: 2,4,5-triamino-6-hydroxypyrimidine sulfate In acetic acid at 38℃; for 5h;
75.5%
1,1,3-tribromoacetone
3475-39-6

1,1,3-tribromoacetone

N-(4-aminobenzoyl)-L-glutamic acid
4271-30-1

N-(4-aminobenzoyl)-L-glutamic acid

2,4,5-triamino-6-hydroxypyrimidine sulfate
35011-47-3

2,4,5-triamino-6-hydroxypyrimidine sulfate

folate
59-30-3

folate

Conditions
ConditionsYield
With sodium carbonate In ethanol; water at 40℃; pH=7.5; Temperature; pH-value;60%
folate
65165-92-6

folate

2-hydroxy-3-oxopropionaldehyde
497-15-4

2-hydroxy-3-oxopropionaldehyde

N-(4-aminobenzoyl)-L-glutamic acid
4271-30-1

N-(4-aminobenzoyl)-L-glutamic acid

folate
59-30-3

folate

7,8-dihydrofolic acid
188497-71-4

7,8-dihydrofolic acid

Na-folate

Na-folate

sodium citrate
68-04-2

sodium citrate

folate
59-30-3

folate

Conditions
ConditionsYield
With sodium hydroxide
folinic acid
58-05-9

folinic acid

alpha cyclodextrin
10016-20-3

alpha cyclodextrin

folate
59-30-3

folate

Conditions
ConditionsYield
In water
folate
59-30-3

folate

N-tert-butoxycarbonyl cystamine
485800-26-8

N-tert-butoxycarbonyl cystamine

tert-butyl 2-{[2-({N2-(4-{[(2-amino-4-hydroxypteridin-6-yl)methyl]amino}benzoyl)-N1-[2-({2-[(tert-butoxycarbonyl)amino]ethyl}dithio)ethyl]-α-glutaminyl}amino)ethyl]dithio}ethylcarbamate
1301165-94-5

tert-butyl 2-{[2-({N2-(4-{[(2-amino-4-hydroxypteridin-6-yl)methyl]amino}benzoyl)-N1-[2-({2-[(tert-butoxycarbonyl)amino]ethyl}dithio)ethyl]-α-glutaminyl}amino)ethyl]dithio}ethylcarbamate

Conditions
ConditionsYield
With pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In water at 100℃;96%
folate
59-30-3

folate

calcium chloride

calcium chloride

C19H17N7O6(2-)*Ca(2+)

C19H17N7O6(2-)*Ca(2+)

Conditions
ConditionsYield
Stage #1: folate With sodium hydroxide at 50℃; for 2h; pH=7.4;
Stage #2: calcium chloride In ethanol; water at 50℃; for 1h;
96%
folate
59-30-3

folate

strontium chloride

strontium chloride

C19H17N7O6(2-)*Sr(2+)

C19H17N7O6(2-)*Sr(2+)

Conditions
ConditionsYield
Stage #1: folate With sodium hydroxide at 50℃; for 2h; pH=7.4;
Stage #2: strontium chloride In ethanol; water at 50℃; for 1h;
95%
ethanol
64-17-5

ethanol

folate
59-30-3

folate

C23H27N7O6

C23H27N7O6

Conditions
ConditionsYield
With methanesulfonic acid at 20℃;95%
1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

folate
59-30-3

folate

N-hydroxysuccinimide folate
153445-05-7

N-hydroxysuccinimide folate

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In dimethyl sulfoxide at 20℃; for 24h; Darkness;94%
With dicyclohexyl-carbodiimide In dimethyl sulfoxide at 20℃; for 0.0833333h; Inert atmosphere;53%
With dicyclohexyl-carbodiimide In dimethyl sulfoxide at 50℃; for 6h;
1-amino-2-azidoethane
87156-40-9

1-amino-2-azidoethane

folate
59-30-3

folate

C21H23N11O5

C21H23N11O5

Conditions
ConditionsYield
Stage #1: folate With 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate In dimethyl sulfoxide; N,N-dimethyl-formamide at 0℃; for 1h; Inert atmosphere; Cooling with ice;
Stage #2: 1-amino-2-azidoethane In dimethyl sulfoxide; N,N-dimethyl-formamide at 0℃; for 2h; Inert atmosphere; Cooling with ice;
94%
Stage #1: folate With 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide In dimethyl sulfoxide at 20℃; Inert atmosphere; Darkness;
Stage #2: 1-amino-2-azidoethane In dimethyl sulfoxide for 24h; Inert atmosphere; Darkness;
84%
folate
59-30-3

folate

Propargylamine
2450-71-7

Propargylamine

propargylfolate

propargylfolate

Conditions
ConditionsYield
Stage #1: folate With 1-hydroxy-pyrrolidine-2,5-dione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide for 0.5h; Cooling with ice;
Stage #2: Propargylamine In N,N-dimethyl-formamide at 20℃; for 24h;
93%
folate
59-30-3

folate

butan-1-ol
71-36-3

butan-1-ol

C27H35N7O6

C27H35N7O6

Conditions
ConditionsYield
With methanesulfonic acid at 20℃;92%
formaldehyd
50-00-0

formaldehyd

folate
59-30-3

folate

calcium 5-methyl-tetrahydrofolate

calcium 5-methyl-tetrahydrofolate

Conditions
ConditionsYield
Stage #1: folate With sodium tetrahydroborate; edetate disodium; sodium hydroxide In water at 25 - 92℃;
Stage #2: formaldehyd With hydrogenchloride In water at 0 - 10℃; pH=9; Further stages;
91.35%
tert-butyl N-(6-aminohexyl)carbamate
51857-17-1

tert-butyl N-(6-aminohexyl)carbamate

folate
59-30-3

folate

γ-{[tert-butyl-N-(6-aminohexyl)]carbamate}folic acid
850754-81-3

γ-{[tert-butyl-N-(6-aminohexyl)]carbamate}folic acid

Conditions
ConditionsYield
With pyridine; dicyclohexyl-carbodiimide In dimethyl sulfoxide at 20℃; for 18h; Inert atmosphere;91%
folate
59-30-3

folate

Propargylamine
2450-71-7

Propargylamine

propargyl folic acid
1009599-12-5

propargyl folic acid

Conditions
ConditionsYield
Stage #1: folate With 1-hydroxy-pyrrolidine-2,5-dione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide for 0.5h; Cooling with ice;
Stage #2: Propargylamine In N,N-dimethyl-formamide at 20℃; Cooling with ice;
90%
Stage #1: folate With 1-hydroxy-pyrrolidine-2,5-dione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide for 0.5h; Cooling with ice;
Stage #2: Propargylamine In N,N-dimethyl-formamide at 25℃; for 24h;
71.2%
Stage #1: folate With 1-hydroxy-pyrrolidine-2,5-dione; 1,2-dichloro-ethane In N,N-dimethyl-formamide for 0.5h; Cooling with ice;
Stage #2: Propargylamine In N,N-dimethyl-formamide at 20℃; for 24h;
nickel(II) chloride hexahydrate

nickel(II) chloride hexahydrate

water
7732-18-5

water

hydrazine hydrate
7803-57-8

hydrazine hydrate

folate
59-30-3

folate

[Ni2(FA)(N2H4)3(H2O)2(OH-)2]

[Ni2(FA)(N2H4)3(H2O)2(OH-)2]

Conditions
ConditionsYield
Stage #1: nickel(II) chloride hexahydrate; water; folate In ethanol for 0.166667h; Sonication;
Stage #2: hydrazine hydrate In ethanol at 120℃; for 12h; pH=10.5; Autoclave;
90%
propan-1-ol
71-23-8

propan-1-ol

folate
59-30-3

folate

C25H31N7O6

C25H31N7O6

Conditions
ConditionsYield
With methanesulfonic acid at 20℃;89%
methanol
67-56-1

methanol

folate
59-30-3

folate

C21H23N7O6
319919-60-3

C21H23N7O6

Conditions
ConditionsYield
With methanesulfonic acid at 20℃;87%
adamantylmethylamine
17768-41-1

adamantylmethylamine

folate
59-30-3

folate

C30H36N8O5

C30H36N8O5

Conditions
ConditionsYield
Stage #1: folate With 1-hydroxy-pyrrolidine-2,5-dione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dimethyl sulfoxide for 1h; Inert atmosphere; Darkness;
Stage #2: adamantylmethylamine With triethylamine In dimethyl sulfoxide for 48h; Inert atmosphere; Darkness;
86%

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