Synthesis and in vitro cytotoxicity of hexacyclic Camptothecin analogues

DOI: 10.1016/S0960-894X(99)00555-7

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3203 - 3206 (1999)

Update date:2022-08-03

Topics:

Authors:

Jew, Sang-Sup

Kim, Hee-Jin

Goo Kim, Myoung

Roh, Eun-Young

Il Hong, Chung

Kim, Joon-Kyum

Lee, Jun-Hee

Lee, Heesoon

Park, Hyeung-Geun

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(99)00555-7

A series of C(7)-N-alkylaminoethyl-C(10), C(11)-methylenedioxy- and ethylenedioxy-camptothecin (3a-g, 4a-h) were prepared. Their syntheses and in vitro cytotoxicity were reported. Among 15 derivatives, 3a and 3b showed more potent cytotoxicity than Campto

Full text of DOI:10.1016/S0960-894X(99)00555-7

Products guided by the article

Product name:isopropyl-[3-(6-nitro-benzo[1,3]dioxol-5-yl)-3-oxo-propyl]-carbamic acid benzyl ester

Cas No:256411-58-2

R&D Labs maybe for 256411-58-2

A-Chem Technologies Co.,Ltd.

Contact:+86-512-69561895

Address:No.111, Building A4, 218 Xinghu Street, Suzhou Industrial Park, P. R. China
Xi'an Costrong Pharmaceutical Co., Ltd.

Contact:029- 68576496

Address:Room 2004,Shuibao Building,No.190,South Erhuan Rd, Yanta District,Xi'an,Shaan Xi,China
Afine Chemicals Limited

website:http://www.afinechem.com

Contact:+86-571-85134551

Address:No. 206 Zhen Hua Road, Hangzhou 310030, Zhejiang, China
Ji'an Hairui Natural Plant Co. Ltd.

Contact:0796-8105528

Address:Meilin industry park, Qingyuan district Ji'an City, Jiangxi Province
Weifang Dongxing Chitosan Factory

website:http://dxchitosan.lookchem.com/

Contact:13475651157

Address:Weifang city ,shandong province

Relevant to this article

Synthetic oligonucleotide combinatorial libraries. 3. Synthesis of polyaminonucleosides

Doi:10.1080/07328319908044615
(1999)
[2+2] Cycloaddition and ring expansion reactions of cyclic phosphonium and aminophosphonium salts: Synthesis and structure of the first eight-membered ylide-type heterocycles

Doi:10.1039/a807891b
(1999)
Synthesis of 1,5-bifunctional organolithium reagents by a double directed ortho-metalation: Direct transformation of esters into 1,8-dimethoxy-acridinium salts

Doi:10.1016/j.tet.2018.04.060
(2018)
Oxidative-substitution reactions of polycyclic aromatic hydrocarbons with iodine(III) sulfonate reagents

Doi:10.1016/j.tetlet.2006.07.114
(2006)
Synthesis of sialic acid derivatives based on chiral substrate-controlled stereoselective aldol reactions using pyruvic acid oxabicyclo[2.2.2]octyl orthoester

Doi:10.1039/c6ob02412b
(2017)
IRIDOIDS: THE STRUCTURE ELUCIDATION OF SPECIONIN BASED ON CHEMICAL EVIDENCE AND 1H NMR ANALYSIS

Doi:10.1016/S0040-4020(01)82089-5
(1986)

Article Doi