Synthesis and in vitro cytotoxicity of hexacyclic Camptothecin analogues

DOI: 10.1016/S0960-894X(99)00555-7

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3203 - 3206 (1999)

Update date:2022-08-03

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Authors:

Jew, Sang-Sup

Kim, Hee-Jin

Goo Kim, Myoung

Roh, Eun-Young

Il Hong, Chung

Kim, Joon-Kyum

Lee, Jun-Hee

Lee, Heesoon

Park, Hyeung-Geun

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Article abstract of DOI:10.1016/S0960-894X(99)00555-7

A series of C(7)-N-alkylaminoethyl-C(10), C(11)-methylenedioxy- and ethylenedioxy-camptothecin (3a-g, 4a-h) were prepared. Their syntheses and in vitro cytotoxicity were reported. Among 15 derivatives, 3a and 3b showed more potent cytotoxicity than Campto

Full text of DOI:10.1016/S0960-894X(99)00555-7

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