Bioorganic and Medicinal Chemistry p. 2105 - 2111 (2001)
Update date:2022-08-05
Topics:
Schulze, Oliver
Schmidt, Ulrich
Voss, Juergen
Nebeling, Bruno
Adiwidjaja, Gunadi
Scharwaechter, Klaus
The configuration of the diastereoisomers of 6-(4-methylthiophenyl)-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline 1 (McN-5652) is determined and unequivocally assigned by NMR spectroscopy (NOE measurements) and an X-ray structural analysis of the trans diastereoisomer. The enantiomers of cis-1 are separated by preparative HPLC on a chiral phase. One of the enantiomers of cis-1 represents the precursor for imaging the serotonin 5-HT transporter with positron emission tomography (PET).
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