6-(4-(methylthio)phenyl)-2,3,6,10b-tetrahydropyrrolo[2,1-a]isoquinolin-5(1H)-one

Base Information

Chemical Name:6-(4-(methylthio)phenyl)-2,3,6,10b-tetrahydropyrrolo[2,1-a]isoquinolin-5(1H)-one
CAS No.:370102-66-2
Molecular Formula:C₁₉H₁₉NOS
Molecular Weight:309.432
Hs Code.:

Synonyms:6-(4-(methylthio)phenyl)-2,3,6,10b-tetrahydropyrrolo[2,1-a]isoquinolin-5(1H)-one

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Chemical Property of 6-(4-(methylthio)phenyl)-2,3,6,10b-tetrahydropyrrolo[2,1-a]isoquinolin-5(1H)-one

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Technology Process of 6-(4-(methylthio)phenyl)-2,3,6,10b-tetrahydropyrrolo[2,1-a]isoquinolin-5(1H)-one

There total 7 articles about 6-(4-(methylthio)phenyl)-2,3,6,10b-tetrahydropyrrolo[2,1-a]isoquinolin-5(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 125330-79-2
1-[2-hydroxy-2-(4-methylthiophenyl)]ethanoyl-2-phenylpyrrolidine

: 370102-66-2
6-(4-(methylthio)phenyl)-2,3,6,10b-tetrahydropyrrolo[2,1-a]isoquinolin-5(1H)-one

Guidance literature:: With sulfuric acid; In trifluoroacetic acid; at 20 ℃;
DOI:10.1016/S0968-0896(01)00117-1

Reference yield: 29.0%

: 2-(4-(methylthio)phenyl)-1-(2-phenylpyrrolidin-1-yl)ethan-1-one

: 370102-66-2
6-(4-(methylthio)phenyl)-2,3,6,10b-tetrahydropyrrolo[2,1-a]isoquinolin-5(1H)-one

Guidance literature:: 2-(4-(methylthio)phenyl)-1-(2-phenylpyrrolidin-1-yl)ethan-1-one; With 2-iodopyridine; trifluoromethylsulfonic anhydride; In acetonitrile; at 0 ℃; for 0.25h; Schlenk technique; Inert atmosphere; Molecular sieve;

With 2,6-lutidine N-oxide; In acetonitrile; at 0 - 110 ℃; for 2h; chemoselective reaction; Schlenk technique; Inert atmosphere; Molecular sieve; Sealed tube;
DOI:10.1002/anie.201701538

Reference yield:

: 1006-64-0
2-(phenyl)pyrrolidine

: 370102-66-2
6-(4-(methylthio)phenyl)-2,3,6,10b-tetrahydropyrrolo[2,1-a]isoquinolin-5(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / TsOH / xylene

2: 92 percent / conc. H₂SO₄ / trifluoroacetic acid / 20 °C

With sulfuric acid; toluene-4-sulfonic acid; In trifluoroacetic acid; xylene;
DOI:10.1016/S0968-0896(01)00117-1