ONE-POT SYNTHESIS OF ALKYL 3-ARYL-2-(4-PHENYL-1H-1,2,3-TRIAZOL-1-YL)...
737
Beeler, A.B., ACS Med. Chem. Lett., 2016, vol. 7,
p. 929.
(3Harom), 7.55 с (1Harom), 7.82 d (2Harom, J 7.1 Hz),
8.72 s (1H, Htriazole). Found, %: C 57.65; H 4.13; N
10.95. C18H15Cl2N3O2. Calculated, %: C 57.46; H 4.02;
N 11.17.
8. Casimiro-Garcia, A., Bigge, C.F., Davis, J.A., Padali-
no, T., Pulaski, J., Ohren, J.F., McConnell, P.,
Kane, C.D., Royer, L.J., Stevens, K.A., Auerbach, B.,
Collard, W., McGregor, C., and Song, K., Bioorg. Med.
Chem., 2009, vol. 17, p. 7113.
Methyl 2-methyl-3-(3-trifluoromethylphenyl)-2-
(4-phenyl-1H-1,2,3-triazol-1-yl)propanoate (8e).
Yield 0.23 g (59%), mp 107–108°С. 1H NMR
spectrum (500 MHz, DMSO-d6), δ, ppm: 1.79 s (3H,
СН3), 3.55 d (1H, CH2, J 13.7 Hz), 3.77 d (1H, CH2, J
13.7 Hz), 3.77 s (3H, СН3), 7.17 s (1H, Н2arom), 7.26 d
(1Harom, J 7.4 Hz), 7.35 t (1H, Н5arom, J 7.4 Hz), 7.43–
7.64 m (5Harom), 7.86 d (1Harom, J 7.4 Hz), 8.72 s (1H,
9. Pokhodylo, N.T., Top. Heterocycl. Chem., 2015, vol. 40,
p. 269.
10. Chittaboina, S., Xie, F., and Wang, Q.,
Tetrahedron Lett., 2005, vol. 46, p. 2331. doi 10.1016/
j.tetlet.2005.01.175
11. Sharpless, W.D., Wu, P., Hansen, T.V., and Lindberg, J.G.,
J. Chem. Educ., 2005, vol. 82, p. 1833.
Htriazole). Found, %: C 61.50; H 4.43; N 10.65.
12. Kacprzak, K., Synlett., 2005, p. 943. doi 10.1055/
C20H18F3N3O2. Calculated, %: C 61.69; H 4.66; N
10.79.
s-2005-864809
13. Molander, G.A. and Ham, J., Org. Lett., 2006, vol. 8,
p. 2767.
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