Bioorganic and Medicinal Chemistry Letters p. 2859 - 2861 (2002)
Update date:2022-07-29
Topics:
Pouget, Christelle
Fagnere, Catherine
Basly, Jean-Philippe
Habrioux, Gerard
Chulia, Albert Jose
Two 4-imidazolylflavans were synthesized and their relative stereochemistry was established by 1H and 13C NMR data. These compounds were tested for their activity to inhibit aromatase. It was observed that the introduction of an imidazolyl group at carbon 4 on flavan nucleus led to potent molecules.
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