Journal of Medicinal Chemistry p. 626,628 (1976)
Update date:2022-08-05
Topics:
Temple et al.
The central nervous system (CNS) activities of a number of soterenol analogs have been investigated, and several of these compounds possessed potent morphine antagonistic and anorexiant properties. The CNS activity of these compounds was enhanced by certain lipophilic [e.g., 1,1-dimethyl-2-phenethyl (43) or cyclopropyl (40 and 44)] nitrogen substituents; however, minor structural changes on either the aromatic or side-chain moieties drastically reduced central activity. Toxicity in this series was related to the inherent alpha-adrenergic stimulating component (direct or indirect).
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Doi:10.1002/chem.201500573
(2015)Doi:10.1246/bcsj.57.1425
(1984)Doi:10.1039/c29690001071
(1969)Doi:10.1007/BF00925652
()Doi:10.1021/acsmedchemlett.5b00202
(2015)Doi:10.1039/c39750000939
(1975)
