STUDY OF THE HYDROXYLATION OF N-SUBSTITUTED 1,2,5,6-TETRAHYDROPYRIDINES

Article abstract of DOI:10.1007/BF00553699

N-Substituted 1,2,5,6-tetrahydropyridines are readily converted to the corresponding 1,2-diols by treatment with an aqueous solution of potassium permanganate in a neutral medium.The yields of the desired products depend on the character of the substituent attached to the nitrogen atom and decrease in the case of N-methyl-1,2,5,6-tetrahydropyridines as a consequence of the formation of side products formed as a result of more profound oxidation.The acylation of the synthesized diols was studied.The three-dimensional structures of the synthesized cis-diols were established by IR spectroscopy.