Tetrahedron p. 6615 - 6619 (2003)
Update date:2022-08-05
Topics:
Rys, Véronique
Couture, Axel
Deniau, Eric
Grandclaudon, Pierre
The first total synthesis of the alkaloid fumaridine 1a is reported. The key step is the assemblage of the arylmethylene isoindolinone 2a (E) by Horner reaction between the phosphorylated isoindolinone 3a and the suitably substituted benzaldehyde 4. N-Lactam deprotection and concomitant E→Z isomerization complete the synthesis of the title compound.
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(2013)
