A novel class of highly potent and selective A1 adenosine antagonists: Structure-affinity profile of a series of 1,8-naphthyridine derivatives

Article abstract of DOI:10.1021/jm990321p

A series of 1,8-naphthyridine derivatives (12-36), bearing a phenyl group in position 2 and various substituents in positions 4 and 7, were synthesized in an attempt to obtain potent, selective antagonists for the A₁ adenosine receptor subtype.