Synthesis of selenium-derivatized cytidine and oligonucleotides for X-ray crystallography using MAD

Article abstract of DOI:10.1021/ol0365077

Synthesis of the novel 2′-Se-cytidine phosphoramidite was achieved via transformation of the uridine analogue to the cytidine derivative in high yield. This 2′-Se-cytidine phosphoramidite was used to synthesize selenium-derivatized DNA and RNA oligonucleo