170118-60-2Relevant academic research and scientific papers
β-Ethoxyvinyl polyfluoroalkyl ketones - versatile synthones in fluoroorganic chemistry
Gerus, I. I.,Gorbunova, M. G.,Kukhar, V. P.
, p. 195 - 198 (1994)
We have found readily available β-ethoxyvinyl trifluoromethyl ketone to be a convenient and comprehensive starting material for the synthesis of various fluoro-containing compounds such as heterocycles, enones, enaminones and chelate complexes.The 4,4,4-trifluoro-3-oxo-1-butenyl group formed by β-ethoxyvinyl trifluoromethyl ketone is a suitable protecting group for the N-H terminal of amino acids in peptide synthesis.The formation of peptides using these protected amino acids occurs without racemization. - Keywords: β-Ethoxyvinyl polyfluoroalkyl ketones; Synthones; Protecting group; Peptide synthesis; Reactions
Synthesis and properties of β-ethoxyvinyl polyfluoroalkyl ketones
Gorbunova, Marine G.,Gerus, Igor I.,Kukhar, Valery P.
, p. 738 - 742 (2000)
A number of β-ethoxyvinyl polyfluoroalkyl ketones were synthesized by acylation of ethyl vinyl ether with acid chlorides containing polyfluoroalkyl groups of different composition and structure. Some typical nucleophilic reactions of the title compounds with amines were carried out. Two new fluoro-containing pyrimidinoles were synthesized by the reaction of β- ethoxyvinyl polyfluoroalkyl ketones with urea.
3-Trifloxy-3-trifluoromethylpropeniminium triflate: Reaction with aromatic amines - An efficient synthesis of 2-trifluoromethylquinolines
Baraznenok, Ivan L.,Nenajdenko, Valentine G.,Balenkova, Elizabeth S.
, p. 937 - 941 (2007/10/03)
The reaction of iminium triflates 2 and 7 with various aromatic amines were investigated. The 2-R(f)-substituted quinolines 3 and 8 were prepared in excellent yields by the reaction of 2 and 7, respectively, with substituted anilines. The reactions of 2 a
