3′-C-branched LNA-type nucleosides locked in an N-type furanose ring conformation: Synthesis, incorporation into oligocleoxynucleotides, and hybridization studies

Article abstract of DOI:10.1021/jo049159a

Three protected 3′-C-branched LNA-type phosphoramidite building blocks 17, 27, and 38, containing furanose rings locked in an N-type conformation, were synthesized from a known 3-C-allyl allofuranose derivative using strategies relying on the introduction