Synthesis and Anticholinergic Properties of the Enantiomers of 4-(Isopropylamino)-2-(2-pyridyl)-2-phenylbutyramide, the Mono-N-dealkylated Metabolite of Disopyramide

DOI: 10.1021/jm00137a024

Source and publish data:

Journal of Medicinal Chemistry p. 614 - 617 (1981)

Update date:2022-08-02

Topics:

Authors:

Nelson, Wendel L.

Sneed, Cherilyn K.

Giacomini, Kathleen M.

Giacomini, John C.

Stauss, John

et al. et al.

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Article abstract of DOI:10.1021/jm00137a024

The 2R and 2S enantiomers of 4-isopropyl-2-(2-pyridyl)-2-phenylbutyramide <(2R)-2 and (2S)-2> were prepared from the respective 2R and 2S enantiomers of disopyramide <(2R)-1 and (2S)1> by oxidation with peracid, Cope elimination, and subsequent zinc/HCl r

Full text of DOI:10.1021/jm00137a024

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Product name:(R)-4-(Hydroxy-isopropyl-amino)-2-phenyl-2-pyridin-2-yl-butyramide

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