Journal of Medicinal Chemistry p. 1313 - 1316 (1982)
Update date:2022-08-04
Topics:
Caranikas, S.
Mizrahi, J.
Escher, E.
Regoli, D.
Several substance P analogues containing various D-amino acid modifications have been synthesized by the solid-phase procedure, detached from the solid support by ammonolysis, and purified by gel filtration combined with reversed-phase chromatography.Three compounds were fair to very potent competitive antagonists of substance P on three bioassays, i.e., guinea pig ileum, rabbit mesenteric vein, and guinea pig trachea.
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