Synthesis and biological evaluation of novel pyridazinone-based α4 integrin receptor antagonists

DOI: 10.1021/jm060031q

Source and publish data:

Journal of Medicinal Chemistry p. 3402 - 3411 (2006)

Update date:2022-08-03

Topics:

Authors:

Gong, Yong

Barbay, J. Kent

Dyatkin, Alexey B.

Miskowski, Tamara A.

Kimball, Edward S.

Prouty, Stephen M.

Fisher, M. Carolyn

Santulli, Rosemary J.

Schneider, Craig R.

Wallace, Nathaniel H.

Ballentine, Scott A.

Hageman, William E.

Masucci, John A.

Maryanoff, Bruce E.

Damiano, Bruce P.

Andrade-Gordon, Patricia

Hlasta, Dennis J.

Hornby, Pamela J.

He, Wei He, Wei

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Article abstract of DOI:10.1021/jm060031q

A novel series of pyridazinone-functionalized phenylalanine analogues was prepared and evaluated for inhibition of cellular adhesion mediated by α₄β₁/VCAM-1 and α₄β ₇MAdCAM-1 interactions. Concise syntheses were

Full text of DOI:10.1021/jm060031q

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