Synthesis and triplex-forming ability of 2′,4′-BNAs bearing imidazoles as a nucleobase

Article abstract of DOI:10.1248/cpb.53.843

To expand the sequence of double-stranded DNA (dsDNA) targets in a triplex formation, 2′,4′-BNAs (2′-O,4′-C-methylene bridged nucleic acids) having imidazoles as a nucleobase were synthesized and incorporated into oligonucleotides. Triplex-forming ability