56583-59-6Relevant academic research and scientific papers
Solvolysis of pyridoxal hydrochloride in alcohols
Nagata,Yoda,Matsushima
, p. 1019 - 1022 (1993)
HPLC, 1H-NMR, MS and product analysis showed that pyridoxal hydrochloride was solvolyzed in methanol to form pyridoxal monomethylacetal. The reaction followed first order kinetics with the rate constant of 1.45 x 10-4 s-1 at 40 °C. The rate was not appreciably enhanced in the presence of an excess amount of HCl. The reaction was greatly retarded by addition of an equimolar amount of KOH. The results showed that the pyridinium-phenol species of pyridoxal hemiacetal is reactive. The reaction is responsible for the 'aging' of alcoholic solutions of pyridoxal, which has caused poor reproducibility of the kinetic data for the formation of Schiff bases with amino acids.
1-Alkoxy-7-hydroxy-1,3-dihydrofuro[3,4-c]pyridinium Salts
Bagautdinova, R. Kh.,Kibardina,Pudovik,Pudovik,Burilov,Trifonov,Dobrynin
, (2018)
New salt structures have been synthesized from pyridoxal and various organic and inorganic acids.
Reaction of Pyridoxal with Hydrophosphoryl Compounds
Kibardina, Lyudmila K.,Trifonov, Alexey V.,Dobrynin, Alexey B.,Pudovik, Michael A.,Burilov, Alexander R.,Sinyashin, Oleg G.
, p. 221 - 227 (2016)
The products of carbonyl phosphonylation of pyridoxal with dialkylphosphinous acid, alkylphosphinic acid ethyl esters, and phosphorous acid dialkyl (or diphenyl) esters have been obtained for the first time. In some cases, the products of addition are hyd
Versatile synthesis of 6-alkyl and aryl substituted pyridoxal derivatives
Kim, Yong-Chul,Jacobson, Kenneth A.
, p. 119 - 122 (2007/10/03)
A versatile and convenient procedure for the functional derivatization with carbon substituents at the 6-position of pyridoxal using a Grignard reaction upon a protected N-isobutoxycarbonyloxypyridoxal chloride and Heck reactions with protected 6-vinylpyr
Pyridoxal Derivatives as Probes for Water Concentration in Non-aqueous Solvents
Brown, Linda,Johnston, Grant A.,Suckling, Colin J.,Halling, Peter J.,Valivety, Rao H.
, p. 2777 - 2780 (2007/10/02)
In order to provide a basis for the design of spectrofluorimetric indicators for water activity or concentration in organic solvents a series of O- and N-alkylated pyridoxal derivatives has been prepared.The compounds were examined for their ability to exhibit a shift in fluorescence emission wavelength on complexation with water.The shift in fluorescence on complexation with water previously observed (Yunxiang and Xin, Talanta, 1984, 31, 556) was confirmed for pyridoxal itself but alkylation of the oxygen functionalities blocked the fluorescence shift.In contrast, a strong enhancement in emission intensity but no shift in emission wavelength was observed with the N-methylpyridoxal.From these studies, it appears that modification at the nitrogen or, presumably, at C-2 or C-6 are the only available sites for the development of useful compounds from the pyridoxal prototype.
