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1-Methoxy-6-Methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol (also known as pyridoxal monomethylacetal) is a solvolysis product formed when pyridoxal hydrochloride reacts with methanol, following first-order kinetics. The reaction is not significantly accelerated by excess HCl but is strongly inhibited by KOH, indicating the reactive species is the pyridinium-phenol form of pyridoxal hemiacetal. 1-Methoxy-6-Methyl-1.3-dihydrofuro[3.4-c]pyridin-7-ol contributes to the "aging" of pyridoxal solutions in alcohols, leading to inconsistent kinetic data in Schiff base formation with amino acids.

56583-59-6

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56583-59-6 Usage

Molecular Structure

1-Methoxy-6-Methyl-1.3-dihydrofuro[3.4-c]pyridin-7-ol is a complex organic compound with a pyridine derivative containing a furo-3.4-c-pyridine ring system.

Functional Groups

The compound has a methoxy group, a methyl group, and a hydroxyl group attached to the molecule.

Potential Applications

1-Methoxy-6-Methyl-1.3-dihydrofuro[3.4-c]pyridin-7-ol may have potential applications in pharmaceutical or medicinal chemistry due to its unique structure and functional groups.

Biological Activity

1-Methoxy-6-Methyl-1.3-dihydrofuro[3.4-c]pyridin-7-ol may possess biological activity or therapeutic potential.

Further Research

Additional research is likely needed to fully understand the properties and potential uses of 1-Methoxy-6-Methyl-1.3-dihydrofuro[3.4-c]pyridin-7-ol.

Check Digit Verification of cas no

The CAS Registry Mumber 56583-59-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,6,5,8 and 3 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 56583-59:
(7*5)+(6*6)+(5*5)+(4*8)+(3*3)+(2*5)+(1*9)=156
156 % 10 = 6
So 56583-59-6 is a valid CAS Registry Number.

56583-59-6Relevant academic research and scientific papers

Solvolysis of pyridoxal hydrochloride in alcohols

Nagata,Yoda,Matsushima

, p. 1019 - 1022 (1993)

HPLC, 1H-NMR, MS and product analysis showed that pyridoxal hydrochloride was solvolyzed in methanol to form pyridoxal monomethylacetal. The reaction followed first order kinetics with the rate constant of 1.45 x 10-4 s-1 at 40 °C. The rate was not appreciably enhanced in the presence of an excess amount of HCl. The reaction was greatly retarded by addition of an equimolar amount of KOH. The results showed that the pyridinium-phenol species of pyridoxal hemiacetal is reactive. The reaction is responsible for the 'aging' of alcoholic solutions of pyridoxal, which has caused poor reproducibility of the kinetic data for the formation of Schiff bases with amino acids.

1-Alkoxy-7-hydroxy-1,3-dihydrofuro[3,4-c]pyridinium Salts

Bagautdinova, R. Kh.,Kibardina,Pudovik,Pudovik,Burilov,Trifonov,Dobrynin

, (2018)

New salt structures have been synthesized from pyridoxal and various organic and inorganic acids.

Reaction of Pyridoxal with Hydrophosphoryl Compounds

Kibardina, Lyudmila K.,Trifonov, Alexey V.,Dobrynin, Alexey B.,Pudovik, Michael A.,Burilov, Alexander R.,Sinyashin, Oleg G.

, p. 221 - 227 (2016)

The products of carbonyl phosphonylation of pyridoxal with dialkylphosphinous acid, alkylphosphinic acid ethyl esters, and phosphorous acid dialkyl (or diphenyl) esters have been obtained for the first time. In some cases, the products of addition are hyd

Versatile synthesis of 6-alkyl and aryl substituted pyridoxal derivatives

Kim, Yong-Chul,Jacobson, Kenneth A.

, p. 119 - 122 (2007/10/03)

A versatile and convenient procedure for the functional derivatization with carbon substituents at the 6-position of pyridoxal using a Grignard reaction upon a protected N-isobutoxycarbonyloxypyridoxal chloride and Heck reactions with protected 6-vinylpyr

Pyridoxal Derivatives as Probes for Water Concentration in Non-aqueous Solvents

Brown, Linda,Johnston, Grant A.,Suckling, Colin J.,Halling, Peter J.,Valivety, Rao H.

, p. 2777 - 2780 (2007/10/02)

In order to provide a basis for the design of spectrofluorimetric indicators for water activity or concentration in organic solvents a series of O- and N-alkylated pyridoxal derivatives has been prepared.The compounds were examined for their ability to exhibit a shift in fluorescence emission wavelength on complexation with water.The shift in fluorescence on complexation with water previously observed (Yunxiang and Xin, Talanta, 1984, 31, 556) was confirmed for pyridoxal itself but alkylation of the oxygen functionalities blocked the fluorescence shift.In contrast, a strong enhancement in emission intensity but no shift in emission wavelength was observed with the N-methylpyridoxal.From these studies, it appears that modification at the nitrogen or, presumably, at C-2 or C-6 are the only available sites for the development of useful compounds from the pyridoxal prototype.

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