38. Approaches to the Synthesis of Cytochalasans. Part 4. Improved Synthesis of the Tetrahydroisoindoline Subunits Related to the Cytochalasins and Aspochalasins

DOI: 10.1002/hlca.19830660206

Source and publish data:

Helvetica Chimica Acta p. 450 - 465 (1983)

Update date:2022-08-04

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Authors:

Schmidlin, Tibur

Bruckhardt, Peter E.

Waespe-Sarcevic, Nada

Tamm, Christoph

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Article abstract of DOI:10.1002/hlca.19830660206

A general scheme for the synthesis of the tetrahydroisoindolinone moiety of naturally occurring cytochalasans and unnatural analogs was developed.The keystep consist of the intermolecular <2+4>cycloaddition of 4-methylsorbinol (7) to an alkylidene malonic

Full text of DOI:10.1002/hlca.19830660206

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