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High purity 99% terbinafine hydrochloride,Terbinafine HCl factory in stock
Cas No: 78628-80-5
No Data 1 Kilogram 1 Metric Ton/Month Shaanxi Mingqi Chemical Co., Ltd Contact Supplier
Terbinafine HCl
Cas No: 78628-80-5
USD $ 90.0-90.0 / Kilogram 1 Kilogram 15 Kilogram/Day Jinan Hongfangde Pharmatech Co.,Ltd Contact Supplier
Terbinafine HCl
Cas No: 78628-80-5
No Data 1 Kilogram 5000 Kilogram/Month Jinan Chenghuishuangda Chemical CO.,Ltd Contact Supplier
High quality of 3-O-Ethyl-L-ascorbic acidTerbinafine Hydrochloride
Cas No: 78628-80-5
USD $ 1.0-1.0 / Metric Ton 1 Metric Ton 1000 Kilogram/Month Career Henan Chemical Co Contact Supplier
Terbinafine hydrochloride (E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalenemethanamine monohydrochloride CAS: 78628-80-5
Cas No: 78628-80-5
USD $ 1.0-1.0 / Gram 5 Gram 1000 Kilogram/Week tonda chem-tech co.,ltd Contact Supplier
Terbinafine Hydrochloride
Cas No: 78628-80-5
No Data No Data Metric Ton/Day APOLLO HEALTHCARE RESOURCES Contact Supplier
Terbinafine Hydrochloride
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USD $ 163.86-163.86 / Kilogram 1 Kilogram 500~1000 Kilogram/Month Metric Ton/Day Wuhan ZeShanCheng Biomedical Technology Co., Ltd. Contact Supplier
Terbinafine hydrochloride
Cas No: 78628-80-5
No Data No Data No Data Hangzhou Sanhe Chemical Co., Ltd. Contact Supplier
High purity Terbinafine Hydrochloride with best price
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Terbinafine hydrochloride with best price and top quality
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78628-80-5 Usage

Chemical Properties

White crystalline powder. Melting point is 204-208 oC.

Indications

1.Skin, hair and nail infection caused by Btrichophyta (white hair versicolor bacterium, Trichophyton mentagrophytes, Trichophyton verrucosum, trichophyton tonsurans and Trichophyton violaceum, etc.), microsporum canis, epidermophyton floccosum, ect.
2.Skin yeast infections caused by all kinds of tinea disease (ringworm of the body, tinea, tinea manus and tinea capitis, etc.) and candida (candida albicans, etc.).
3.Onychomycosis (nail fungus infection) caused by molds.

Definition

ChEBI: A hydrochloride obtained by reaction of terbinafine with one molar equivalent of hydrogen chloride.

Usage and Dosage

Local external use: apply adequate amount to the affected area and its surrounding, 1-2 times a day. Ringworm of the body, 2-4 weeks, tinea of feet and hands, tinea versicolor, 4 to 6 weeks.
Oral: 0.25 grams each time for adult, once per day, period of treatment is as follows:
Skin infection treatment: tinea of feet and hands [toe (means) and plantar]: 2~6 weeks; Ringworm of the body, tinea, 2~4 weeks.
Skin candidiasis: 2~4 weeks. normal skin appearance and loss of infection can only be visible in a few weeks for curing.
Hair and scalp infection treatment: tinea capitis: 4 weeks, tinea capitis most happen in children.
Onychomycosis: The most treatment course of patients is 6 weeks to three months. Young patients with normal growth can shorten the treatment course, and less than 3 months of treatment may be enough in addition to the thumb (foot) armour.
In other cases, the treatment is usually 3 months. Some patients, especially whose thumb (toe) infected, may take 6 months or longer. The treatment may take more than 3 months if the nail grew slowly in the first week. In healing of mycology and stopping for a few months after treatment, the continuous improvement of nail appearance then completely normal can be seen, this is because that the healthy tissue growth needs time.

Uses

Terbinafine hydrochloride is a synthetic allylamine antifungal. It is used to treat dermatophyte infections of the toenail/fingernail, ringworm and jock itch. It is used in adsorption, partition and stability studies.

Usage

Terbinafine hydrochloride is a kind of broad-spectrum dermatologist allyl amine antifungal drugs. It has a significant effect on all kinds of tinea diseases , including fungus, trichophyton, ringworm of the body, tinea, tinea versicolor and onychomycosis caused by dermophyte. It can also be used for bronchial asthma, asthmatic bronchitis and emphysema, etc.
This information is edited by ChemicalBook Xiao Nan.

Chemical Properties

Crystalline Powder

Dermatologist Broad-spectrum Antifungal Drugs

Terbinafine hydrochloride is a kind of broad-spectrum dermatologist allyl amine antifungal drugs. It is developed by Swiss Novartis in the 1980 s, and appeared in the market of UK for the first time in 1991. Approved by FDA of the United States for OTC drugs in 1996, and appeared in the market of the United States in the same year. At present, the drug is been sold in more than 90 countries of the word. It can specificity trouble the late biological decomposition of fungus sterol, selectively inhibit the activity of fungal squalene ring oxidase, and inhibit the squalene epoxidation in the formation of ungal cell membrane, thus to kill or inhibit the active of the fungus. Suitable for treatment of candidiasis skin, such as tinea manuum, tinea, tinea, ringworm of the body, tinea versicolor, it is also the best medicine for the treatment of onychomycosis.
Terbinafine hydrochloride entered the the first batch of country announced OTC directory in 2000. This product belongs to antifungal drugs. It has strong effect on shallow fungal infection, and can cure most of the fungal skin diseases through external use.

Uses

An orally active, antimycotic allylamine related to Naftifine. A specfic inhibitor of squalene epoxidase, a key enzyme in fungal ergosterol biosynthesis. Antifungal.

Pharmacokinetics

According to reports in the literatures, after 250 mg of Terbinafine hydrochloride been taken orally, it reaches peak plasma concentration of 0.97 m ug/ml within 2 hours. The absorption half-life is 0.8 hours, spread half-life is 4.6 hours, the degree of biological application is slightly affected by eating, but not used for dose adjustments. The combination rate of drugs and plasma protein is 99%, and can quickly disperse and concentrate in the lipophilic corneous layer through the dermis. Terbinafine hydrochloride can be spread in the skin, therefore, a very high concentration can be reached in the hair follicle, hair and skin layers of fat, and it can enter in the deck in the last few weeks of healing. The metabolites after the bioconversion have no antifungal activity, then discharged through urine. The half-life is 17 hours, no accumulation in the body, and its steady blood drug concentration is not affected by age. But the alleviation rate can reduce for people with liver and kidney disorders, thus triggers blood drug concentration decreasing.
InChI:InChI=1/C21H25N/c1-21(2,3)15-8-5-9-16-22(4)17-19-13-10-12-18-11-6-7-14-20(18)19/h5-7,9-14H,16-17H2,1-4H3/b9-5+

78628-80-5 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Sigma-Aldrich (Y0000535)  Terbinafinehydrochloride  European Pharmacopoeia (EP) Reference Standard 78628-80-5 Y0000535 1,880.19CNY Detail
Sigma-Aldrich (Y0001143)  Terbinafine for system suitability  European Pharmacopoeia (EP) Reference Standard 78628-80-5 Y0001143 1,880.19CNY Detail
Sigma-Aldrich (PHR1298)    pharmaceutical secondary standard; traceable to USP and PhEur 78628-80-5 PHR1298-1G 732.19CNY Detail
TCI America (D2049)  trans-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthylmethylamine Hydrochloride  >98.0%(HPLC)(T) 78628-80-5 5g 2,250.00CNY Detail
TCI America (D2049)  trans-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthylmethylamine Hydrochloride  >98.0%(HPLC)(T) 78628-80-5 1g 690.00CNY Detail

78628-80-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name terbinafine hydrochloride

1.2 Other means of identification

Product number -
Other names Terbinafine hydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:78628-80-5 SDS

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