Recueil des Travaux Chimiques des Pays-Bas p. 143 - 150 (1993)
Update date:2022-07-30
Topics:
Wieringa, J.
Meerendonk, A. van den
Steenvoorden, J.
Heeres, G.
Bakel, F. van
et al.
A series of 1-<2-<(2-phenoxyphenyl)methoxy>ethyl>-4-(3-phenylpropyl)piperazines 17-50 (Figure 1) were prepared and tested as inhibitors of biogenic amine re-uptake.In our search for antidepressants, the relationship between their in vitro and in vivo activity as dopamine-re-uptake inhibitors is described quantitatively by using Retention Index values determined by reversed-phase liquid chromatography.
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