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1809249-37-3

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Product FOB Price Min.Order Supply Ability Supplier
High quality Remdesivir supplier
Cas No: 1809249-37-3
USD $ 100.0-100.0 / Gram 100 Gram 10000 Metric Ton/Day Shanghai Upbio Tech Co.,Ltd Contact Supplier
GS-5734with factory price
Cas No: 1809249-37-3
No Data No Data No Data Wuhan Sun-shine Bio-technology Corporation Limited Contact Supplier
Remdesivir China supplier
Cas No: 1809249-37-3
No Data 1 Milligram 1 Gram/Month Hangzhou ZeErRui Chemical Co., Ltd. Contact Supplier
Remdesivir
Cas No: 1809249-37-3
No Data 1 Gram 1 Kilogram/Month Boc Sciences Contact Supplier
GS-5734
Cas No: 1809249-37-3
No Data 1 Gram 10 Gram/Month Lalpharm Co., Ltd., Contact Supplier

1809249-37-3 Usage

Product Description:

Novel inhibitor of the replication of several taxonomically diverse RNA viruses such as Middle East respiratory syndrome virus, Ebola virus, Lassa fever virus, Junin virus and respiratory syncytial virus, while having low cytotoxicity in a wide-range of cell lines

Remdesivir Properties

Background Information

Remdesivir is a nucleoside analogue, with effective antiviral activity, with EC50s of 74 nM for ARS-CoV and MERS-CoV in HAE cells, and 30 nM for murine hepatitis virus in delayed brain tumor cells. 
Remdesivir, also known as GS-5734, is an antiviral drug, a novel nucleotide analog prodrug. It was developed by Gilead Sciences as a treatment for filovirus infections such as Ebola virus disease and Marburg virus, though it has subsequently also been found to show reasonable antiviral activity against more distantly related viruses such as respiratory syncytial virus, Junin virus, Lassa fever virus, and MERS-coronavirus. GS-5734 was rapidly pushed through clinical trials due to the 2013–2016 West African Ebola virus epidemic crisis, eventually being used in at least one human patient despite its early development stage at the time. Preliminary results have been promising, and further clinical trials are planned.
GS-5734 (Remdesivir) is a monophosphoramidate prodrug of adenosine analogue that exhibits antiviral activity against multiple variants of EBOV (EC50=70-140 nM) and other filoviruses (EC50=0.019-1.48 uM) in cell-based assays; suppresses EBOV replication and protects 100% of EBOV-infected animals against lethal disease, ameliorating clinical disease signs and pathophysiological markers.

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