Bioorganic and Medicinal Chemistry Letters p. 4539 - 4544 (2004)
Update date:2022-09-26
Topics:
Shankaran
Donnelly, Karla L.
Shah, Shrenik K.
Guthikonda, Ravindra N.
MacCoss, Malcolm
Humes, John L.
Pacholok, Stephen G.
Grant, Stephan K.
Kelly
Wong
Syntheses and evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2- imines as inhibitors of nitric oxide synthase (NOS) are discussed. An extensive SAR was established for pyrrolidin-2-imines class of compounds. The amidines came out as the most potent inhibitors in addition to displaying selectivity.
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Doi:10.1016/S0040-4039(01)90035-8
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