Structure-activity relationship study on col-003, a protein-protein interaction inhibitor between collagen and Hsp47

Article abstract of DOI:10.1248/cpb.c19-00634

This study demonstrates the structure-activity relationship of Col-003, a potent collagen-heat-shock protein 47 (Hsp47) interaction inhibitor. Col-003 analogues were successfully synthesized by Pd(0)-catalyzed cross-coupling reactions of 5-bromosalicylald