Asymmetric 1,4-addition of diethylzinc to α,β-unsaturated enones catalyzed by chiral imino-thiophosphoramide ligands and copper(I)

Article abstract of DOI:10.1016/j.tetasy.2003.11.015

In the presence of a catalytic amount of chiral imino-thiophosphoramide ligand L7 (6mol%) and Cu(I) salt (3mol%), the asymmetric addition of diethylzinc to α,β-unsaturated carbonyl compounds could be achieved in good yields with moderate ees (up to 75% ee) at -20°C in toluene. A novel chiral imino-thiophosphoramide ligand system for this asymmetric 1,4-addition reaction has been explored.