Synthetic Posttranslational Modifications: Chemical Catalyst-Driven Regioselective Histone Acylation of Native Chromatin

DOI: 10.1021/jacs.7b02138

Source and publish data:

Journal of the American Chemical Society p. 7568 - 7576 (2017)

Update date:2022-08-04

Topics:

Authors:

Amamoto, Yoshifumi

Aoi, Yuki

Nagashima, Nozomu

Suto, Hiroki

Yoshidome, Daisuke

Arimura, Yasuhiro

Osakabe, Akihisa

Kato, Daiki

Kurumizaka, Hitoshi

Kawashima, Shigehiro A.

Yamatsugu, Kenzo

Kanai, Motomu

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Article abstract of DOI:10.1021/jacs.7b02138

Posttranslational modifications (PTMs) of histones play an important role in the complex regulatory mechanisms governing gene transcription, and their dysregulation can cause diseases such as cancer. The lack of methods for site-selectively modifying nati

Full text of DOI:10.1021/jacs.7b02138

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