Ring Transformation Equilibrium (Bond Switch) in the 5-(2-Aminovinyl)isothiazole System via Hypervalent Sulfurane. Synthesis, Structure Determination, and Kinetic Study

DOI: 10.1021/ja00295a026

Source and publish data:

Journal of the American Chemical Society p. 2721 - 2730 (1985)

Update date:2022-08-02

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Authors:

Akiba, Kin-ya

Kashiwagi, Kohichi

Ohyama, Yoshihiko

Yamamoto, Yoshuke

Ohkata, Katsuo

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Article abstract of DOI:10.1021/ja00295a026

Reaction of 3-aryl-5-methylisothiazoles (4) with aromatic nitriles afforded the adducts 3, 5-(2-amino-2-arylvinyl)-3-arylisothiazole derivatives, in the presence of LDA.By employing p-chlorobenzonitrile-15N, the presence of ring transformation from one is

Full text of DOI:10.1021/ja00295a026

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Product name:15N-labeled 3-(p-chlorophenyl)-5-<2-<(tert-butyldimethylsilyl)amino>-2-(p-chlorophenyl)vinyl>isothiazole

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