132388-59-1 Usage
Description
Fmoc-N-trityl-L-asparagine, also known as Fmoc-Asn(Trt)-OH, is an amino acid derivative characterized by its white crystal powder form. It is utilized in chemical synthesis and peptide chemistry due to its unique properties and reactivity.
Uses
Used in Chemical Synthesis:
Fmoc-N-trityl-L-asparagine is used as a building block in chemical synthesis for the creation of complex organic molecules. Its trityl group provides steric hindrance and protection, which is crucial for the selective synthesis of target compounds.
Used in Peptide Chemistry:
In peptide chemistry, Fmoc-N-trityl-L-asparagine is used as a protected amino acid for the stepwise assembly of peptide chains. The Fmoc (9-fluorenylmethoxycarbonyl) group serves as a protecting group for the amino group, allowing for the controlled addition of amino acids during solid-phase peptide synthesis. This protection is essential to prevent unwanted side reactions and ensure the correct sequence of the peptide.
Used in Pharmaceutical Industry:
Fmoc-N-trityl-L-asparagine is used as a key intermediate in the synthesis of pharmaceutical compounds, particularly in the development of peptide-based drugs. Its role in facilitating the synthesis of complex peptide structures makes it a valuable asset in the discovery and production of new therapeutic agents.
Used in Research and Development:
In research and development settings, Fmoc-N-trityl-L-asparagine is used as a reagent for studying the properties and interactions of amino acids and peptides. Its controlled synthesis and modification capabilities make it an ideal candidate for exploring the structure-function relationships in biologically active peptides.
Check Digit Verification of cas no
The CAS Registry Mumber 132388-59-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,2,3,8 and 8 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 132388-59:
(8*1)+(7*3)+(6*2)+(5*3)+(4*8)+(3*8)+(2*5)+(1*9)=131
131 % 10 = 1
So 132388-59-1 is a valid CAS Registry Number.
InChI:InChI=1/C38H32N2O5/c41-35(40-38(26-14-4-1-5-15-26,27-16-6-2-7-17-27)28-18-8-3-9-19-28)24-34(36(42)43)39-37(44)45-25-33-31-22-12-10-20-29(31)30-21-11-13-23-32(30)33/h1-23,33-34H,24-25H2,(H,39,44)(H,40,41)(H,42,43)/p-1/t34-/m0/s1
132388-59-1Relevant articles and documents
Multiple solid phase synthesis via Fmoc-amino acid fluorides
Wenschuh, Holger,Beyermann, Michael,Rothemund, Sven,Carpino, Louis A.,Bienert, Michael
, p. 1247 - 1250 (1995)
In addition to displaying high reactivity, Fmoc-amino acid fluorides are shown to be highly soluble and stable for extended periods in organic solvents such as DMF and therefore to be recommended for use in Multiple Peptide Synthesis. A series of analogs of alamethicin and a partial sequence (22 amino acids) of the CNG-channel forming protein BOVTESTIS have been assembled with excellent results.
NOVEL PEPTIDES DERIVED FROM NCAM (FGLs)
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, (2011/05/05)
The present invention relates to novel compounds comprising at most 13 contiguous amino acid residues derived from the fibronectin type 3,I1 module of neural cell adhesion molecule (NCAM), or a variant or fragment thereof, capable of interacting with an FGFR and thereby the compounds are capable of inducing differentiation, modulating proliferation, stimulate regeneration, neuronal plasticity and/or survival of cells. Further, the present invention relates to the use of said compounds for production of a medicament for treatment of conditions and diseases, wherein NCAM and/or FGFR play a prominent role.
GLP-2 compounds, formulations, and uses thereof
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, (2008/06/13)
The present invention relates to novel human glucagon-like peptide-2 (GLP-2) peptides and human glucagon-like peptide-2 derivatives which have a protracted profile of action as well as polynucleotide constructs encoding such peptides, vectors and host cells comprising and expressing the polynucleotide, pharmaceutical compositions, uses and methods of treatment.