An efficient aldol-based approach for the synthesis of dihydrokawain-5-ol

Article abstract of DOI:10.1016/j.tetasy.2009.08.006

An efficient and simple aldol-based convergent approach toward the total synthesis of (+)- and (-)-dihydrokawain-5-ol is described. The key features of this synthetic strategy include Evans' aldol reaction and an ethyl acetate addition reaction for the formation of the six-membered ring.