CAS No.57-83-0,Progesterone Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	57-83-0
Name:	Progesterone
Article Data:	231
Cas Database

Formula:	C₂₁H₃₀O₂
Molecular Weight:	314.468
Synonyms:	Luteosan;Luteostab;Luteovis;Luteum;Lutex;Lutidon;Lutociclina;Lutocylin;Lutoform;Lutren;Lutromone;NSC 64377;NSC 9704;Prochieve;Progekan;Progestan;Progestasert;Progestogel;Progestol;Progestone;Prolidon;Prontogest;Syntolutan;Utrogest;Utrogestan;Vitarrine;D4-Pregnene-3,20-dione;Natural Micronised Progesterone;Progesterone(8CI);Agolutin;Corluvite;Corporin;Corpus luteum hormone;Crinone;Cyclogest;Duraprogen;Flavolutan;Fologenon;Gestiron;Gestormone;Gestron;Glanducorpin;Gynlutin;Gynolutone;Hormoflaveine;Lugesterone;Luteal Hormone;Luteinique;Luteodyn;Luteogan;Luteopur;Pregn-4-ene-3,20-dione;
EINECS:	200-350-6
Density:	1.08 g/cm³
Melting Point:	128-132 °C(lit.)
Boiling Point:	447.2 °C at 760 mmHg
Flash Point:	166.7 °C
Solubility:	<0.1 g/100 mL at 19 °C in water
Appearance:	Crystalline powder
Hazard Symbols:	Xn, T
Risk Codes:	40-45
Safety:	36/37-45-53
PSA:	34.14000
LogP:	4.72350

Synthetic route

: 1096-38-4
16-dehydroprogesterone

: 57-83-0
Progesterone

Conditions

Conditions	Yield
With phenylsilane; isopropyl alcohol; Mn(dpm)3 at 23℃;	99%
With hydrogen; palladium on activated charcoal In ethyl acetate for 0.75h; Ambient temperature;	89%
With potato dextrose broth medium In ethanol at 24 - 26℃; for 96h; Penicillium decumbens ATCC 10436;	8%
With Lindlar's catalyst Hydrogenation;

: 60037-01-6
C25H36O4

: 57-83-0
Progesterone

Conditions

Conditions	Yield
With perchloric acid In 1,4-dioxane Ambient temperature;	99%

: 60966-36-1
(20S)-21-hydroxy-20-methylpregn-4-en-3-one

: 57-83-0
Progesterone

Conditions

Conditions	Yield
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; oxygen; acetylacetone copper; N,N-diethylaniline In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide at 0℃; for 2h; Solvent; Reagent/catalyst; Temperature; Inert atmosphere;	99%

: 1162-56-7
6-dehydroprogesterone

: 57-83-0
Progesterone

Conditions

Conditions	Yield
With formic acid In isopropyl alcohol at 76 - 80℃; for 6h; Inert atmosphere;	97%
With palladium on activated charcoal Hydrogenation;

: 64-85-7
21-Hydroxyprogesterone

: 57-83-0
Progesterone

Conditions

Conditions	Yield
With methanol; trimethylsilyl iodide In chloroform for 2h; Ambient temperature;	96%
With trimethylsilyl iodide In chloroform for 2h; Ambient temperature;	90%
With trimethylsilyl iodide In chloroform for 2h; Ambient temperature;	90%

: 112251-19-1
3-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>pregna-3,5-diene-20-one

: 57-83-0
Progesterone

Conditions

Conditions	Yield
With hydrogenchloride In tetrahydrofuran; ethanol at 60℃; for 24h;	95%

: 26623-68-7
21-trityloxy-pregn-4-ene-3,20-dione

: 57-83-0
Progesterone

Conditions

Conditions	Yield
With methanol; trimethylsilyl iodide In acetonitrile for 1.3h; Ambient temperature;	94%

: C25H36O4

: 57-83-0
Progesterone

Conditions

Conditions	Yield
With cerium(III) chloride; sodium iodide In acetonitrile for 2h; Ambient temperature;	94%

: 20576-46-9
11-deoxy-21-iodocorticosterone

: 57-83-0
Progesterone

Conditions

Conditions	Yield
With mercaptoacetic acid In various solvent(s) for 0.166667h; Ambient temperature;	93.8%

: 145-13-1
Pregnenolone

: 57-83-0
Progesterone

Conditions

Conditions	Yield
With bromopentacarbonylmanganese(I); N-methyl-N,N-di(2-pyridylmethyl)amine; acetone; sodium t-butanolate In toluene at 90℃; for 24h; Inert atmosphere; Schlenk technique; Darkness;	93%
With <(C4Ph4COHOCC4Ph4)(μ-H)><(CO)4Ru2>; acetone at 56℃; for 12h;	90%
Stage #1: Pregnenolone With cyclohexanone In toluene for 2h; Oppenauer Oxidation; Stage #2: With aluminum isopropoxide In toluene for 1.5h; Oppenauer Oxidation; Reflux;	90%

Raw Materials

108-94-1

108-88-3

64-85-7

57-88-5

152-58-9

556-91-2

30459-98-4

1058-61-3

Downstream Products

50-22-6

570-54-7

68-96-2

600-81-7

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Consensus Reports

NTP 10th Report on Carcinogens. IARC Cancer Review: Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 21 ,1979,p. 491.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 6 ,1974,p. 135.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . EPA Genetic Toxicology Program. Reported in EPA TSCA Inventory.

Specification

The Progesterone, with the CAS registry number 57-83-0,is also known as Progestin; Lutren; Lutein; Flavolutan; Corporin; Luteal hormone; 4-Pregnene-3,20-dione. It belongs to the product categories of Intracellular receptor;Steroid and Hormone.Its EINECS number is 200-350-6. This chemical's molecular formula is C₂₁H₃₀O₂ and molecular weight is 314.47. What's more,Its systematic name is Progesterone.It is a crystalline powder which is the major progestational steroid that is secreted primarily by the corpus luteum and the placenta. Progesterone acts on the uterus, the mammary glands and the brain. It is required in embryo implantation; pregnancy maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from pregnenolone, also serves as an intermediate in the biosynthesis of gonadal steroid hormones and adrenal corticosteroids.

Physical properties about Progesterone are:
(1)ACD/LogP: 3.827; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 3.83; (4)ACD/LogD (pH 7.4): 3.83; (5)ACD/BCF (pH 5.5): 476.94; (6)ACD/BCF (pH 7.4): 476.94; (7)ACD/KOC (pH 5.5): 2876.39; (8)ACD/KOC (pH 7.4): 2876.39; (9)#H bond acceptors: 2; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 1; (12)Index of Refraction: 1.542; (13)Molar Refractivity: 90.955 cm³; (14)Molar Volume: 288.952 cm³; (15)Surface Tension: 41.1710014343262 dyne/cm; (16)Density: 1.088 g/cm³; (17)Flash Point: 166.683 °C; (18)Enthalpy of Vaporization: 70.544 kJ/mol; (19)Boiling Point: 447.151 °C at 760 mmHg; (20)Vapour Pressure: 0 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES:O=C4\C=C2/[C@]([C@H]1CC[C@@]3([C@@H](C(=O)C)CC[C@H]3[C@@H]1CC2)C)(C)CC4;
(2)Std. InChI:InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1;
(3)Std. InChIKey:RJKFOVLPORLFTN-LEKSSAKUSA-N.

Safety Information of Progesterone:
The Progesterone is limited evidence of a carcinogenic effect ,And it may cause cancer .In case of accident or if you feel unwell, seek medical advice immediately (show label where possible). When you use it, wear suitable protective clothing and gloves .Avoid exposure - obtain special instruction before use .

The toxicity data of Progesterone are as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LDLo	intravenous	109mg/kg (109mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: CARDIAC OUTPUT LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Anesthesie, Analgesie, Reanimation. Vol. 14, Pg. 225, 1957.
mouse	LD50	intraperitoneal	460mg/kg (460mg/kg)		"Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 99, 1969.
mouse	LD50	intravenous	79500ug/kg (79.5mg/kg)		Toxicology and Applied Pharmacology. Vol. 1, Pg. 454, 1959.
mouse	LD50	oral	1050mg/kg (1050mg/kg)		"Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 99, 1969.
mouse	LD50	subcutaneous	1470mg/kg (1470mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: CARDIAC OUTPUT LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Anesthesie, Analgesie, Reanimation. Vol. 14, Pg. 225, 1957.
rabbit	LD50	intravenous	39mg/kg (39mg/kg)		"Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 99, 1969.

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