Further Studies on the Ring Transformation of Pyrimido-as-triazine 4-Oxides to Pyrrolopyrimidines Involving 1,3-Dipolar Cycloaddition Reactions

Article abstract of DOI:10.1021/jo00214a002

The reaction of 3-alkyl(or aryl)-6,8-dimethylpyrimido<5,4-e>-as-triazine-5,7(6H,8H)-dione 4-oxides (1a-f) with ethyl phenylpropiolate (EPP) in toluene afforded the unexpected 6-alkyl(or aryl)-5-benzoyl-7-(ethoxy-carbonyl)-1,3-dimethylpyrrolo<3,2-d>pyrimid