Please Rd So Cn oA tda vd aj un sc te ms argins
Page 6 of 8
ARTICLE
Journal Name
1
3
7
8
(
1
2
s, 3 H); C NMR (125 MHz, CDCl ) δ = 141.3, 139.5, 135.6,
3
Carethers, J. A. Kennedy, D. O. Thueson, J. C. Chestnut, R. L.
DOI: 10.1039/C5RA24851E
30.4, 128.8, 125.6, 124.6, 122.3, 120.8, 119.1, 110.8, 99.4,
0.7; Anal. Calcd. for C H NS: C, 75.28; H, 5.47; N, 5.85 %;
found: C, 75.29; H, 5.48; N, 5.84 %.
Adolphson and M. C. Conroy, J. Med. Chem., 1989, 32, 1360.
(a) G. De Martino, G. La Regina, A. Coluccia, M. C. Edler, M.
C. Barbera, A. Brancale, E. Wilcox, E. Hamel, M. Artico and R.
Silvestri, J. Med. Chem., 2004, 47, 6120; (b) G. De Martino,
M. C. Edler, G. La Regina, A. Coluccia, M. C. Barbera, D.
Barrow, R. I. Nicholson, G. Chiosis, A. Brancale, E. Hamel, M.
Artico and R. Silvestri, J. Med. Chem., 2006, 49, 947; (c) G. La
Regina, M. C. Edler, A. Brancale, S. Kandil, A. Coluccia, F.
Piscitelli, E. Hamel, G. De Martino, R. Matesanz, J. F. Díaz, A.
I. Scovassi, P. Ennio, A. Lavecchia, E. Novellino, M. Artico and
R. Silvestri, J. Med. Chem., 2007, 50, 2865.
15 13
1
6a
3
%
8
7
-Methyl-2-(phenylthio)-1H-indole (4a) Yield: (114 mg) 95
; White solid; mp 75-77 C; H NMR (400 MHz, CDCl ): δ =
3
.28 (br s, 1 H), 7.55 (d, J = 6 Hz, 1 H), 7.33 (d, J = 6.4 Hz, 1 H),
.19 (t, J = 5.6 Hz, 1 H), 7.12 (t, J = 6 Hz, 1 H), 6.97-6.90 (m, 5
H), 2.41 (s, 3H); C NMR (100 MHz, CDCl ) δ = 140.8, 136.6,
31.1, 129.1, 127.6, 126.3, 125.2, 123.5, 121.3, 120.1, 112,
00.8, 10.4; Anal. Calcd. for C H NS: C, 75.28; H, 5.47; N, 5.85
. Found: C, 75.26; H, 5.48; N, 5.84 %.
o
1
13
3
1
1
%
9
1
(a) P. Hamel, J. Org. Chem., 2002, 67, 2854; (b) M. Raban and
L.-J. Chern, J. Org. Chem., 1980, 45, 1688.
1
5 13
0 (a) L.-H. Zou, J. Reball, J. Mottweiler and C. Bolm, Chem.
Commun., 2012, 48, 11307; (b) G. La Regina, V. Gatti, V.
Famiglini, F. Piscitelli and R. Silvestri, ACS Comb. Sci., 2012,
Bis(4-nitrophenyl)disulfide (Ha)Yield: 75 %; Yellow solid; mp
92-194 C; H NMR (400 MHz, CDCl ): δ = 8.37 (d, J = 8.0 Hz, 4
3
H), 7.88 (d, J = 8.0 Hz, 4 H); Anal. Calcd. for C H N O S : C,
6.75; H, 2.60; N, 9.09 %; found: C, 46.78; H, 2.63; N, 9.06 %.
o
1
14, 258; (c) W. Ge and Y. Wei, Synthesis 2012, 934. (d) W. Ge
1
and Y. Wei, Green Chem., 2012, 14, 2066. (e) Z. Li, J. Hong
and X. Zhou, Tetrahedron, 2011, 67, 3690; (f) X.-L. Fang, R.-Y.
Tang, P. Zhong and J.-H. Li, Synthesis, 2009, 4183; (h) P. Sang,
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12 8 2 4 2
4
(
g) Ch. D. Prasad, S. Kumar, M. Sattar, A. Adhikary and S.
Acknowledgements
The authors wish to thank All India Council of Technical
Education (AICTE), New Delhi [8023/ BOR/RID/RPS (NER)-
Kumar, Org. Biomol. Chem., 2013, 11, 8096; (i) R. Rahaman,
N. Devi and P. Barman, Tetrahedron Lett., 2015, 56, 4224.
1 (a) J. S. Yadav, B. V. S. Reddy, Y. J. Reddy and K. Praneeth,
Synthesis, 2009, 1520; (b) J. S. Yadav, B. V. S. Reddy and Y. J.
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Koyabu, T. Nishimura and S. Uemura, J. Org. Chem., 2004,
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6
8/2010-11] for financial support for this work. MHRD, Govt.
of India is acknowledged for the doctorate fellowship (MHRD
GATE fellowship) received by R.F.R. and N.D. Authors are also
thankful to CSIR-NEIST Jorhat and IIT Guwahati for spectral
analysis.
69, 7688; (d) K. M. Schlosser, A. P. Krasutsky, H. W. Hamilton,
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