100-32-3

Basic information

• Product Name: 4,4'-Dinitrodiphenyl disulfide
• Synonyms: P-NITROPHENYLDISULFIDE;P,P'-DINITRODIPHENYL DISULFIDE;4,4'-DINITRO DIPHENYL DISULFIDE;4-NITROPHENYL DISULFIDE;4-NITROPHENYL SULFIDE;BIS(P-NITROPHENYL) DISULFIDE;BIS(4-NITROPHENYL) DISULFIDE;DI(4-NITROPHENYL) DISULFIDE
• CAS NO: 100-32-3
• Molecular Formula: C₁₂H₈N₂O₄S₂
• Molecular Weight: 308.33
• EINECS: 202-840-5
• Product Categories: Phenyls & Phenyl-Het;Phenyls & Phenyl-Het;Building Blocks;Chemical Synthesis;Organic Building Blocks;Sulfides/Disulfides;Sulfur Compounds
• Mol File: 100-32-3.mol
• Article Data: 252

Chemical Properties

• Melting Point: 181.0 to 186.0 °C
• Boiling Point: 478.783 °C at 760 mmHg
• Flash Point: 243.359 °C
• Appearance: yellow or tan powder
• Density: 1.5285 (rough estimate)
• Refractive Index: 1.6510 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• Stability: Stable. Incompatible with strong oxidizing agents, strong bases.
• CAS DataBase Reference: 4,4'-Dinitrodiphenyl disulfide(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4'-Dinitrodiphenyl disulfide(100-32-3)
• EPA Substance Registry System: 4,4'-Dinitrodiphenyl disulfide(100-32-3)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 20/21/22-40
• Safety Statements: 36
• WGK Germany: 3
• RTECS: JO1550000
• Hazardous Substances Data: 100-32-3(Hazardous Substances Data)

Usage

Chemical Properties

yellow or tan powder

Uses

Different sources of media describe the Uses of 100-32-3 differently. You can refer to the following data:
1. Reactant or reagent involved in:? ;Electrophilic cyclization of 2-alkynylanisoles1 or alkynylanilines2? ;Oxidative chlorination to sulfonyl chlorides3? ;Arylation with triarylbismuthanes4? ;Decarboxylative cross-coupling with dialkoxybenzoic acids5? ;Disulfidation of alkenes6
2. Reactant or reagent involved in:Electrophilic cyclization of 2-alkynylanisoles or alkynylanilinesOxidative chlorination to sulfonyl chloridesArylation with triarylbismuthanesDecarboxylative cross-coupling with dialkoxybenzoic acidsDisulfidation of alkenes

Synthetic route

para-nitrobenzenethiol (1849-36-1) → di(p-nitrophenyl) disulfide (100-32-3)

Conditions	Yield
With air In dimethyl sulfoxide at 80℃;	100%
1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione In chloroform at 20℃; for 0.0166667h;	100%
CoCl2 In acetonitrile Ambient temperature;	99%

(4-nitro-phenyl)-m-tolyl sulfone (77853-01-1) → di(p-nitrophenyl) disulfide (100-32-3) + Toluene-3-thiosulfonic acid; compound with ammonia (77853-09-9) + 4-nitro-aniline (100-01-6)

Conditions	Yield
With sulfur; ammonia at 100℃; for 2h; titanium autoclave;	A 43% B 100% C 40%

1-methoxy-4-((4-nitrophenyl)sulfonyl)benzene (22865-57-2) → di(p-nitrophenyl) disulfide (100-32-3) + 4-Methoxy-benzenethiosulfonic acid; compound with ammonia (77853-03-3) + 4-nitro-aniline (100-01-6)

Conditions	Yield
With sulfur; ammonia at 100℃; for 2h; titanium autoclave;	A 56% B 100% C 32%
With sulfur; ammonia at 100℃; for 2h; Product distribution; titanium autoclave; various reactions temp. and amounts of S8;

para-nitrophenyl bromide (586-78-7) → di(p-nitrophenyl) disulfide (100-32-3)

Conditions	Yield
With 1,10-Phenanthroline; potassium sulfide; iron oxide; potassium hydroxide In N,N-dimethyl-formamide at 120℃; for 0.5h; Inert atmosphere; Green chemistry;	98%
With dmap; nickel(II) chloride hexahydrate; potassium thioacyanate; N,N-dimethyl-formamide at 140℃; for 15h;	92%
With copper(l) iodide; hexachloroethane; sodium carbonate; thiourea In water at 120℃; for 13h;	87%

4-nitrophenyl sulfone (1156-50-9) → di(p-nitrophenyl) disulfide (100-32-3) + bis(4-nitrophenyl)sulfide (1223-31-0) + 4-Nitro-benzenethiosulfonic acid; compound with ammonia (74236-92-3)

Conditions	Yield
With sulfur; ammonia at 40℃; for 2h; titanium autoclave;	A 38% B n/a C 98%

4-nitrophenylthiolate (45797-13-5) → di(p-nitrophenyl) disulfide (100-32-3)

Conditions	Yield
With 2-bromo-2-nitro-1,3-propanediol In methanol for 48h; Irradiation;	98%
With 2-bromo-2-nitro-1,3-propanediol In methanol Mechanism; Product distribution; Irradiation; other reagent and solvent;	98%

4-chlorobenzonitrile (100-00-5) → di(p-nitrophenyl) disulfide (100-32-3)

Conditions	Yield
With 1,10-Phenanthroline; potassium sulfide; iron oxide; potassium hydroxide In N,N-dimethyl-formamide at 120℃; for 0.5h; Inert atmosphere; Green chemistry;	97%
With sodium sulfide pentahydrate In N,N-dimethyl-formamide at 40 - 100℃; for 6h; Reagent/catalyst; Temperature; Solvent; Inert atmosphere;	92.8%
With sodium disulfide In 1-methyl-pyrrolidin-2-one	69%

4-Nitrobenzenesulfonyl chloride (98-74-8) → di(p-nitrophenyl) disulfide (100-32-3)

Conditions	Yield
With ziconium(IV) oxychloride octahydrate; sodium iodide In water at 90℃; for 0.25h;	95%
With tetra-(n-butyl)ammonium iodide In N,N-dimethyl-formamide at 20℃; for 20h; chemoselective reaction;	91%
With triphenylphosphine In tetrahydrofuran at 0℃;	75%

C18H18N4O8S2 (111680-13-8) → di(p-nitrophenyl) disulfide (100-32-3) + diethylazodicarboxylate - triphenylphosphine (DEAD-Ph3P) (58477-00-2)

Conditions	Yield
With triphenylphosphine In benzene at 20℃; for 1h;	A 95% B n/a

C18H18N4O8S2 (111680-13-8) + triphenylphosphine (603-35-0) → di(p-nitrophenyl) disulfide (100-32-3) + diethylazodicarboxylate - triphenylphosphine (DEAD-Ph3P) (58477-00-2)

Conditions	Yield
In benzene at 20℃; for 1h;	A 95% B n/a

C14H13NO5S (77863-74-2) → di(p-nitrophenyl) disulfide (100-32-3) + 3-Ethoxy-benzenethiosulfonic acid; compound with ammonia (77853-06-6) + 4-nitro-aniline (100-01-6)

Conditions	Yield
With sulfur; ammonia at 100℃; for 2h; titanium autoclave;	A 47% B 94% C 40%

(p-Tol)3Bi=C(CO2Me){C(CO2Me)=NSO2Ph} + para-nitrobenzenethiol (1849-36-1) → dimethyl 2-(N-(phenylsulfonyl))aminofumarate + di(p-nitrophenyl) disulfide (100-32-3) + tri(p-tolyl)bismuth (5142-75-6)

Conditions	Yield
In dichloromethane Bi compd. added to CH2Cl2 soln. of 4-nitrobenzenethiol (molar ratio 1:2) at -78°C; warmed to room temp. with stirring; concd. under reduced pressure; recrystd. from CH2Cl2-hexane;	A 92% B 92% C 94%

4-nitrophenylhydrazine hydrochloride (636-99-7) → di(p-nitrophenyl) disulfide (100-32-3)

Conditions	Yield
With sulfur; oxygen; 1,8-diazabicyclo[5.4.0]undec-7-ene In water; N,N-dimethyl-formamide at 100℃; under 3750.38 Torr; for 18h; Sealed tube; Schlenk technique;	94%

1,3-Dichloro-5-(4-nitro-benzenesulfonyl)-benzene (77853-02-2) → di(p-nitrophenyl) disulfide (100-32-3) + 3,5-Dichloro-benzenethiosulfonic acid; compound with ammonia (77853-10-2) + 4-nitro-aniline (100-01-6)

Conditions	Yield
With sulfur; ammonia at 100℃; for 2h; titanium autoclave;	A 42% B 93% C 40%

p-nitrophenyl-N-(p-toluenesulfonyl)sulfinimidoyl chloride (5184-32-7) + triphenylphosphine (603-35-0) → di(p-nitrophenyl) disulfide (100-32-3) + Triphenylphosphine oxide (791-28-6) + N-p-tolylsulfonylphosphine imide (1058-14-6)

Conditions	Yield
Stage #1: p-nitrophenyl-N-(p-toluenesulfonyl)sulfinimidoyl chloride; triphenylphosphine In benzene at 20℃; for 0.5h; Stage #2: With water In benzene for 5h; Further stages.;	A 86% B 93% C 82%

p-nitrobenzene iodide (636-98-6) → di(p-nitrophenyl) disulfide (100-32-3)

Conditions	Yield
With dmap; nickel(II) chloride hexahydrate; potassium thioacyanate; N,N-dimethyl-formamide at 140℃; for 15h;	92%
With copper(l) iodide; hexachloroethane; sodium carbonate; thiourea In water at 120℃; for 11h;	91%
With 1,10-Phenanthroline; copper(II) choride dihydrate; tetrabutyl ammonium fluoride; caesium carbonate; sulfur In water at 100℃; for 24h; Sealed tube;	86%

4-nitrobenzenesulfenyl chloride (937-32-6) → di(p-nitrophenyl) disulfide (100-32-3)

Conditions	Yield
With triphenylphosphine In acetonitrile for 2h; Ambient temperature;	90%
With triethylamine In acetonitrile Ambient temperature; overnight;	75%
With cyclooctatetraene dianion bipotassium salt In tetrahydrofuran at -40℃; for 0.5h; Product distribution;
With cyclooctatetraene dianion bipotassium salt In tetrahydrofuran at -40℃; for 0.5h; Yield given;
Multi-step reaction with 2 steps 1: 70 percent / diethyl ether / 1 h / -50 - 20 °C 2: 85 percent / SeCl4 / 1,2-dimethoxy-ethane / 2 h / 0 °C View Scheme

1-methoxy-3-(4-nitrobenzenesulfonyl)benzene (77863-75-3) → di(p-nitrophenyl) disulfide (100-32-3) + 3-Methoxy-benzenethiosulfonic acid; compound with ammonia (77853-08-8) + 4-nitro-aniline (100-01-6)

Conditions	Yield
With sulfur; ammonia at 100℃; for 2h; titanium autoclave;	A 55% B 90% C 33%

N-(benzenesulfonyl)-3-phenyloxaziridine (113548-13-3) + para-nitrobenzenethiol (1849-36-1) → di(p-nitrophenyl) disulfide (100-32-3) + N-benzylidenephenylsulfonamide (13909-34-7) + benzaldehyde (100-52-7)

Conditions	Yield
for 4.5h; Product distribution;	A 90% B 75% C 30%

4-Methoxybenzenethiol (696-63-9) + para-nitrobenzenethiol (1849-36-1) → di(p-nitrophenyl) disulfide (100-32-3) + 4,4'-dimethoxyphenyl disulfide (5335-87-5) + 1-(4-methoxyphenyl)-2-(4-nitrophenyl)disulfane (20168-74-5)

Conditions	Yield
Stage #1: 4-Methoxybenzenethiol; para-nitrobenzenethiol With dmap; water In ethanol at 20℃; for 0.0833333h; Stage #2: With iodine In ethanol at 70℃; for 3h; Sealed tube;	A 2% B 5% C 90%

tris(4-nitrophenyl) trithioarsenite → di(p-nitrophenyl) disulfide (100-32-3)

Conditions	Yield
With iodine In dichloromethane	86%

p-nitro-N,N-bis(trimethylsilyl)benzenesulfenamide (135577-95-6) → di(p-nitrophenyl) disulfide (100-32-3) + Se, N2

Conditions	Yield
With selenium tetrachloride In 1,2-dimethoxyethane at 0℃; for 2h;	A 85% B n/a

4-nitrobenzenesulfenyl chloride (937-32-6) → 1-methylthio-4-nitro-benzene (701-57-5) + di(p-nitrophenyl) disulfide (100-32-3)

Conditions	Yield
With tetramethylstannane; tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran at 25℃; for 4h;	A n/a B 84%

thiophenol (108-98-5) + para-nitrobenzenethiol (1849-36-1) → di(p-nitrophenyl) disulfide (100-32-3) + 4-nitrophenyl phenyl disulfide (20168-72-3) + diphenyldisulfane (882-33-7)

Conditions	Yield
Stage #1: thiophenol; para-nitrobenzenethiol With dmap; water In ethanol at 20℃; for 0.0833333h; Stage #2: With iodine In ethanol at 70℃; for 3h; Sealed tube;	A 2% B 80% C 2%

(4-nitro-phenyl)-o-tolyl sulfone (42085-91-6) → di(p-nitrophenyl) disulfide (100-32-3) + Toluene-2-thiosulfonic acid; compound with ammonia (77853-12-4) + 4-nitro-aniline (100-01-6)

Conditions	Yield
With sulfur; ammonia at 100℃; for 1h; titanium autoclave;	A 32% B 79% C 18%

p-nitrophenyl-N-(p-toluenesulfonyl)sulfinimidoyl fluoride + triphenylphosphine (603-35-0) → C20H18N3O6S3(1-)*C24H19NO2PS(1+) + di(p-nitrophenyl) disulfide (100-32-3) + Triphenylphosphine oxide (791-28-6) + N-p-tolylsulfonylphosphine imide (1058-14-6)

Conditions	Yield
In benzene at 20℃; for 4h;	A 91.5 % Spectr. B 79% C 66% D 4%

p-Chlorothiophenol (106-54-7) + para-nitrobenzenethiol (1849-36-1) → 4,4'-dichlorodiphenyl disulfide (1142-19-4) + di(p-nitrophenyl) disulfide (100-32-3) + 1-(4-chlorophenyl)-2-(4-nitrophenyl)disulfane (20168-75-6)

Conditions	Yield
Stage #1: p-Chlorothiophenol; para-nitrobenzenethiol With dmap; water In ethanol at 20℃; for 0.0833333h; Stage #2: With iodine In ethanol at 70℃; for 3h; Sealed tube;	A 5% B 2% C 79%

para-nitrobenzenethiol (1849-36-1) + benzyl alcohol (100-51-6) → di(p-nitrophenyl) disulfide (100-32-3) + 1-(benzylsulphanyl)-4-Nitrobenzene (27691-43-6)

Conditions	Yield
at 180℃; Catalytic behavior; Inert atmosphere; Autoclave;	A 17% B 78%

3-methoxybenzenethiol (15570-12-4) + para-nitrobenzenethiol (1849-36-1) → di(p-nitrophenyl) disulfide (100-32-3) + bis(3-methoxyphenyl)disulfide (59014-89-0) + 1-(3-methoxyphenyl)-2-(4-nitrophenyl)disulfane

Conditions	Yield
Stage #1: 3-methoxybenzenethiol; para-nitrobenzenethiol With dmap; water In ethanol at 20℃; for 0.0833333h; Stage #2: With iodine In ethanol at 70℃; for 3h; Sealed tube;	A 2% B 5% C 78%

para-nitrobenzenethiol (1849-36-1) + 1-dodecylthiol (112-55-0) → didodecyl disulfide (2757-37-1) + di(p-nitrophenyl) disulfide (100-32-3) + 1-dodecyl-2-(4-nitrophenyl)disulfane

Conditions	Yield
Stage #1: para-nitrobenzenethiol; 1-dodecylthiol With dmap; water In ethanol at 20℃; for 0.0833333h; Stage #2: With iodine In ethanol at 70℃; for 3h; Sealed tube;	A 5% B 11% C 78%

tris(3,4,5-trifluorophenyl)boroxine (223440-94-6) + di(p-nitrophenyl) disulfide (100-32-3) → (3,4,5-trifluorophenyl)-4-nitrophenylsulfide (1229514-26-4)

Conditions	Yield
With copper(l) iodide; 1,10-Phenanthroline; oxygen In water; dimethyl sulfoxide at 90℃; under 757.576 Torr; for 6.5h;	99%

di(p-nitrophenyl) disulfide (100-32-3) → para-nitrobenzenethiol (1849-36-1)

Conditions	Yield
With magnesium In methanol for 0.166667h; Ambient temperature;	98%
With sodium tetrahydroborate In tetrahydrofuran; methanol at 50℃; for 1h;	89%
With sodium tetrahydroborate; lithium chloride In tetrahydrofuran at 0 - 35℃;	85%

di(p-nitrophenyl) disulfide (100-32-3) → 4-nitrophenylsulphur trifluoride (1526-28-9)

Conditions	Yield
With potassium fluoride; chlorine In acetonitrile at 20℃; for 4.5h;	98%
With silver(II) fluoride In 1,1,2-Trichloro-1,2,2-trifluoroethane Heating;
With bis(fluoroxy)methane In acetonitrile at -20℃;

2-methyl-1H-indole (95-20-5) + di(p-nitrophenyl) disulfide (100-32-3) → 2-methyl-3-((4-nitrophenyl)thio)-1H-indole (1210054-39-9)

Conditions	Yield
With N-Bromosuccinimide In N,N-dimethyl-formamide at 20℃; for 2h; regioselective reaction;	98%
With iron(III) trifluoride; iodine In acetonitrile at 80℃; for 36h; regioselective reaction;	94%
With sodium tetrafluoroborate; potassium iodide In acetonitrile at 60℃; for 6h; Electrolysis;	82%
With silver nitrate In ethanol; N,N-dimethyl-formamide at 70℃; for 8h; Sealed tube;	63%

7,8-benzoquinoline (230-27-3) + di(p-nitrophenyl) disulfide (100-32-3) → 10-(4-nitrophenylsulfanyl)benzo[h]quinoline

Conditions	Yield
With palladium diacetate; copper(ll) bromide In N,N-dimethyl-formamide at 140℃; for 24h; Sealed tube;	98%

di(p-nitrophenyl) disulfide (100-32-3) + 5-nitro-N-(2-(pyridin-2-yl)propan-2-yl)thiophene-2-carboxamide → 5-nitro-3-((4-nitrophenyl)thio)-N-(2-(pyridin-2-yl)propan-2-yl)thiophene-2-carboxamide

Conditions	Yield
With copper diacetate; sodium carbonate In 1,4-dioxane at 130℃; for 12h;	98%

di(p-nitrophenyl) disulfide (100-32-3) + 2-methyl-N-(perfluorophenyl)benzamide → 2-methyl-6-((4-nitrophenyl)thio)-N-(perfluorophenyl)benzamide

Conditions	Yield
With Boc-DL-Leu-OH; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; silver(l) oxide In dichloromethane at 90℃; for 12h; Inert atmosphere; Schlenk technique; Sealed tube;	98%

di(p-nitrophenyl) disulfide (100-32-3) + methyl iodide (74-88-4) → 1-methylthio-4-nitro-benzene (701-57-5)

Conditions	Yield
With water; rongalite; potassium carbonate In N,N-dimethyl-formamide for 0.166667h;	97%
With disodium hydrogenphosphate; sodium dithionite In water; N,N-dimethyl-formamide at 20℃; for 0.2h;	82%

di(p-nitrophenyl) disulfide (100-32-3) + phenylboronic acid (98-80-6) → 4-nitrophenyl phenyl sulfide (952-97-6)

Conditions	Yield
With [2,2]bipyridinyl; copper(l) iodide In water; dimethyl sulfoxide at 100℃; for 12h;	97%
With [2,2]bipyridinyl; copper(l) iodide; air In dimethyl sulfoxide at 100℃; for 12h;	97%

di(p-nitrophenyl) disulfide (100-32-3) + tris(3-fluoro phenyl)boroxine (448-53-3) → (3-fluorophenyl)-4-nitrophenylsulfide (2249-00-5)

Conditions	Yield
With copper(l) iodide; 1,10-Phenanthroline; oxygen In water; dimethyl sulfoxide at 90℃; under 757.576 Torr; for 7h;	97%

di(p-nitrophenyl) disulfide (100-32-3) → 4-nitrobenzenesulfenyl chloride (937-32-6)

Conditions	Yield
With chlorine In tetrachloromethane at 60℃; for 3h;	96%
With chloroform; chlorine unter Ausschluss der Luftfeuchtigkeit;
With chlorine

di(p-nitrophenyl) disulfide (100-32-3) → p-nitrobenzenesulfonic acid (138-42-1)

Conditions	Yield
With dihydrogen peroxide; methyltrioxorhenium(VII) In dichloromethane; acetonitrile at 20℃; for 1h;	96%
With dihydrogen peroxide; trichlorophosphate In water at 80℃; for 1.08333h; Micellar solution;	93%
With nitric acid
With nitric acid

di(p-nitrophenyl) disulfide (100-32-3) → 4-Nitrobenzenesulfonyl chloride (98-74-8)

Conditions	Yield
With dihydrogen peroxide; zirconium(IV) chloride In water; acetonitrile at 25℃; for 0.0166667h;	96%
With N,N,N',N'-tetrachlorobenzene-1,3-disulphonamide; tetrabutyl-ammonium chloride; water In acetonitrile at 0 - 20℃; for 0.333333h;	96%
With trichloroisocyanuric acid; tetrabutylammomium bromide; water In acetonitrile at 0 - 20℃; for 0.333333h;	96%

N-chloroacetamide (598-49-2) + di(p-nitrophenyl) disulfide (100-32-3) → N,N'-diacetyl-p-nitrobenzenesulfinamidine (88951-70-6)

Conditions	Yield
With pyridine In benzene	96%

di(p-nitrophenyl) disulfide (100-32-3) + benzyl bromide (100-39-0) → 1-(benzylsulphanyl)-4-Nitrobenzene (27691-43-6)

Conditions	Yield
With water; rongalite; potassium carbonate In N,N-dimethyl-formamide for 0.25h;	96%
With sodium hydroxide; Aminoiminomethanesulfinic acid; cetyltrimethylammonium chloride In tetrahydrofuran; water for 0.2h; Heating;	92%
With disodium hydrogenphosphate; sodium dithionite In water; N,N-dimethyl-formamide at 20℃; for 0.25h;	73%

di(p-nitrophenyl) disulfide (100-32-3) + 1-dodecylbromide (143-15-7) → p-nitrophenyl n-dodecyl thioether (73520-87-3)

Conditions	Yield
With sodium hydroxide; Aminoiminomethanesulfinic acid; cetyltrimethylammonium chloride In tetrahydrofuran; water for 3.3h; Heating;	96%

di(p-nitrophenyl) disulfide (100-32-3) + 1-phenyl-2-bromoethane (103-63-9) → 1-nitro-4-[(2-phenylethyl)sulfanyl]benzene (60091-82-9)

Conditions	Yield
With sodium hydroxide; Aminoiminomethanesulfinic acid; cetyltrimethylammonium chloride In tetrahydrofuran; water for 2.1h; Heating;	96%

1-iodo-butane (542-69-8) + di(p-nitrophenyl) disulfide (100-32-3) → butyl(4-nitrophenyl)sulfane (27826-43-3)

Conditions	Yield
With water; rongalite; potassium carbonate In N,N-dimethyl-formamide for 0.25h;	96%

di(p-nitrophenyl) disulfide (100-32-3) + 1-bromomethyl-4-nitro-benzene (100-11-8) → 1-nitro-4-(4-nitrophenylmethylthio)benzene (42497-87-0)

Conditions	Yield
With water; rongalite; potassium carbonate In N,N-dimethyl-formamide for 0.166667h;	96%

di(p-nitrophenyl) disulfide (100-32-3) + 2-phenylethynylaniline (13141-38-3) → 3-((4-nitrophenyl)thio)-2-phenyl-1H-indole (1213786-18-5)

Conditions	Yield
With air; palladium dichloride In dimethyl sulfoxide at 80℃; for 24h;	96%
With iodine In toluene at 110℃; for 8h; Schlenk technique;	93%

di(p-nitrophenyl) disulfide (100-32-3) + acetic anhydride (108-24-7) → 1-acetylsulfanyl-4-nitro-benzene (15119-62-7)

Conditions	Yield
With rongalite; cesium fluoride In water; N,N-dimethyl-formamide at 20℃; for 0.0833333h;	96%

indole (120-72-9) + di(p-nitrophenyl) disulfide (100-32-3) → 3-[(4-nitrophenyl)sulfanyl]-1H-indole (72496-80-1)

Conditions	Yield
With iron(III) trifluoride; iodine In acetonitrile at 80℃; for 36h; regioselective reaction;	96%
With iodine; dimethyl sulfoxide In carbonic acid dimethyl ester at 40℃; for 10h;	92%
Stage #1: di(p-nitrophenyl) disulfide With tetrabutylammomium bromide; triethylamine In dichloromethane for 1h; Cooling with ice; Green chemistry; Stage #2: indole In dichloromethane at 70℃; for 3.5h; Green chemistry;	85%

di(p-nitrophenyl) disulfide (100-32-3) + 4-methyl-benzaldehyde (104-87-0) → S-(4-nitrophenyl) 4-methylbenzothioate (39248-99-2)

Conditions	Yield
With tert.-butylhydroperoxide; potassium carbonate In water at 100℃; for 2h;	96%

Upstream product

• 10032-22-1 {[2-amino-6-oxo-5-(4-phenylbutyl)-3,6-dihydropyrimidin-4-yl]methyl}(triphenyl)phosphonium 
• 100321-58-2 3-[(4-aminobenzoyl)(4-methoxybenzyl)amino]-N,N-diethylpropan-1-aminium chloride 
• 100321-54-8 3-[(4-aminobenzoyl)(1-phenylethyl)amino]-N,N-diethylpropan-1-aminium chloride 
• 10032-15-2 Hexyl 2-methylbutyrate 
• 10032-13-0 HEXYL ISOVALERATE STANDARD FOR GC 
• 10032-11-8 FEMA 3498 
• 1003-21-0 5-BROMO-1-METHYL-1H-IMIDAZOLE 
• 10032-08-3 HEPTYL CINNAMATE 
• 10032-05-0 HEPTANAL DIMETHYL ACETAL 
• 10032-02-7 GERANYL CAPROATE 
• 10032-00-5 FEMA 2510 
• 10031-96-6 4-allyl-2-methoxyphenyl formate 
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