Research on antiviral agents. 4. Studies on the chemistry of 6-methyl-2-methoxy-4-O-acyloxy and 6-methyl-2,4-di-O-acyloxypyrimidine derivatives as new acylation reagents and inhibitors of uracil DNA glycosylases.

Article abstract of DOI:10.1016/S0040-4020(01)87037-X

The synthesis of 6-methyl-2-methoxy-4-O-acyloxy and 6-methyl-2,4-di-O-acyloxypyrimidine derivatives 2 and 5 along with their properties as acylating agents of amines, alcohols, thiols and α-amino acids have been reported. Interestingly some of the title products revealed an inhibitory activity against the human and herpetic DNA glycosylases.