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16187-15-8

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16187-15-8 Usage

General Description

1,2,4-Trioxolane,3,5-dimethyl-, trans- is a chemical compound also known as trans-3,5-dimethyl-1,2,4-trioxolane. It is a member of the trioxolane family, which are cyclic peroxides with potential antimalarial activity. 1,2,4-Trioxolane,3,5-dimethyl-, trans- (8CI,9CI) has been studied for its potential use in treating malaria, as it has been shown to exhibit potent activity against the malaria parasite Plasmodium falciparum. Research on this compound and other trioxolanes continues in the pursuit of developing new and effective antimalarial treatments.

Check Digit Verification of cas no

The CAS Registry Mumber 16187-15-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,1,8 and 7 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 16187-15:
(7*1)+(6*6)+(5*1)+(4*8)+(3*7)+(2*1)+(1*5)=108
108 % 10 = 8
So 16187-15-8 is a valid CAS Registry Number.

16187-15-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name trans-3,5-Dimethyl-1,2,4-trioxolane

1.2 Other means of identification

Product number -
Other names trans-2-butene ozonide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:16187-15-8 SDS

16187-15-8Downstream Products

16187-15-8Relevant articles and documents

MECHANISM OF THE OZONOLYSIS OF PROPENE IN THE LIQUID PHASE.

Choe,Srinivasan,Kuczkowski

, p. 4703 - 4704 (1983)

Propylene was ozonized in isobutane, hlorodifluoromethane, and methyl chloride solvents. Propylene ozonide, ethylene ozonide, and 2-butene ozonide (cis and trans isomers) were obtained in ratios of about 82:16:2. The amount of butene ozonide increased while that of ethylene ozonide usually decreased for reactions in the presence of added acetaldehyde. The cis-trans stereochemistry of the butene cross ozonide from propylene was studied at various conditions. Usually the cis isomer was preferentially formed, but addition of acetaldehyde could alter this. The cis-(trans-butene ozonide ratio was 67/33 when formed from cis- or trans-2-butene in CHClF//2 and 50/50 as a cross ozonide from trans-2-pentene. The kinetic secondary isotope effects upon ozonolysis of propene-2-d//1 (k//H/k//D equals 0. 88 (6) and propene-1-d//1 (0. 88 (8) were evaluated. These results are discussed with reference to the Criege mechanism of ozonolysis. 37 refs.

High-Field Rapid Injection NMR: Observation of Unstable Primary Ozonide Intermediates

McGarrity, John F.,Prodolliet, Jacques

, p. 4465 - 4470 (2007/10/02)

A "rapid injection" NMR system is described for use on a 360-MHz superconducting spectrometer.The major advantages of the high-field sytem over our original system are increased sensitivity, resolution, and rapidity.The technique was used to study the ozonolysis of tetramethylethylene and (briefly) cis-but-2-ene, particularly the decomposition of the corresponding primary ozonides 2 and 4, with half-lives of 0.74 and 0.06 s, respectively, at -92 deg C.It was found that the decomposition of 2 in CD2Cl2 (a) had Δ H(excit) = 39 kJ/mol and Δ S(excit) = 28 J/(molK), (b) was unaffected by the presence of TCNE, but (c) was acid-catalyzed.The effects of substituents, solvent, and acid catalysts on the decomposition of primary ozonides are discussed.

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