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Caffeine-H SO : a novel dual acidic catalyst for one-pot…
Typical procedure for preparation of 2H-indazolo[2,1-b]phthalazinetrione
A mixture of dimedone (0.14 g, 1 mmol), phthalhydrazide (0.16 g, 1 mmol),
aromatic aldehyde (1.1 mmol), and caffeine-H SO (0.01 g, 3.4 mol%) was heated
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at 100 °C. Completion of the reaction was indicated by TLC [TLC acetone/n-
hexane (3:10)]. After completion of the reaction, the mixture was washed with water
and the crude product recrystallized in hot ethanol to afford the pure product.
Conclusions
Caffeine-H SO was applied as a novel dual acidic catalyst in one-pot preparation
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of 2H-indazolo[2,1-b]phthalazinetriones. The catalyst was characterized by FT-IR,
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1
H NMR, C NMR, and TGA. According to the obtained results including reaction
time, yield, and recyclability, caffeine-H SO can be considered an efficient catalyst
for this reaction and other organic transformations.
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Acknowledgements We gratefully acknowledge the support of this work by Production Technology
Research Institute of ACECR Research Council.
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