Carbohydrate Research p. 57 - 62 (1999)
Update date:2022-08-17
Topics:
Itabashi, Masaki
Segawa, Kaoru
Ikeda, Yoko
Kondo, Shinichi
Naganawa, Hiroshi
Koyano, Takashi
Umezawa, Kazuo
Microbial and plant secondary metabolites were screened for compounds that are selectively cytotoxic to mutant p53-expressing mouse fibroblasts. As a result, furcreastatin, a novel steroidal saponin, was isolated from an EtOH extract of the leaves of Furcraea foetida. Furcreastatin consisted of hecogenin as the aglycone and a hexasaccharide containing D-galactose, L- rhamnose and four D-glucose residues. The structure was determined to be (3β,5α,25R)-3-hydroxyspirostan-12-one 3-O-[α-L-Rhap-(1→4)-β-D-Glcp- (1→3)-{β-D-Glcp-(1→3)-β-D-Glcp-(1→2)}-β-D-Glcp-(1→4)-β-D-Galp] by extensive NMR spectroscopic studies. Furcreastatin decreased the viability of mutant p53-overexpressing cells with an ED50 of 4.0 μg/mL, and decreased that of the parental cell-line with an ED50 of 9.6 μg/mL. (C) 2000 Elsevier Science Ltd.
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Doi:10.1080/14786419.2016.1233413
(2017)Doi:10.1007/BF01354583
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