D-Galactose

Base Information

• Chemical Name: D-Galactose
• CAS No.: 10257-28-0
• Molecular Formula: C6H12O6
• Molecular Weight: 180.158
• Hs Code.: 2924199090
• European Community (EC) Number: 200-416-4
• DSSTox Substance ID: DTXSID001015860
• Nikkaji Number: J330.863D
• Wikipedia: Galactose
• Wikidata: Q27106307
• Metabolomics Workbench ID: 49825
• ChEMBL ID: CHEMBL195923
• Mol file: 10257-28-0.mol

Synonyms:D Galactose;D-Galactose;Galactopyranose;Galactopyranoside;Galactose

Chemical Property of D-Galactose

Chemical Property:

• Vapor Pressure: 1.83E-08mmHg at 25°C
• Melting Point: 168-170oC(lit.)
• Refractive Index: 1.635
• Boiling Point: 410.797 °C at 760 mmHg
• PKA: 12.12±0.70(Predicted)
• Flash Point: 202.243 °C
• PSA: 110.38000
• Density: 1.732 g/cm³
• LogP: -3.22140
• Solubility.: H2O: 100 mg/mL
• XLogP3: -2.6
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 1
• Exact Mass: 180.06338810
• Heavy Atom Count: 12
• Complexity: 151

Purity/Quality:

98%,99%, ^*data from raw suppliers

Galactose Pharmaceutical Secondary Standard; Certified Reference Material ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Biological Agents -> Monosaccharides and Derivatives
• Canonical SMILES: C(C1C(C(C(C(O1)O)O)O)O)O
• Isomeric SMILES: C([C@@H]1[C@@H]([C@@H]([C@H](C(O1)O)O)O)O)O
• Recent ClinicalTrials: sCD163 and sMR in Wilsons Disease - Associations With Disease Severity and Fibrosis
• Uses: Diagnostic aid (ultrasound contrast medium).

Technology Process of D-Galactose

There total 309 articles about D-Galactose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-nitrophenyl O-(5-acetamido-3,5-dideoxy-α-D-glycero-D-galacto-2-nonulopyranosylonic acid)-(2->6)-β-D-galactopyranoside (81119-31-5) → D-Galactose (10257-28-0) + 4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + cytidine 5'-monophosphate-N-acetylneuraminic acid (55569-66-9) + 4-nitrophenyl-β-D-galactopyranoside (3150-24-1)

Guidance literature:

With Na₃PO₄ buffer; sodium acetate; carboxymethyl-dodecyl-dimethyl-ammonium betaine; sodium chloride; calcium chloride; multistep reaction : 1) bacterial neuraminidase (V. cholera), bovine serum albumin, 2) β-D-galactosidase; colorimetric assay method for determination of linkage specificity of bacterial and viral neuraminidases; other neuraminidases;

DOI:10.1016/0008-6215(91)84090-2

Reference yield:

4-nitrophenyl-β-D-galactopyranoside (3150-24-1) → D-Galactose (10257-28-0) + 4-nitro-phenol (100-02-7,78813-13-5,89830-32-0)

Guidance literature:

With β-D-galactosidase; water; at 30 ℃; pH 5.5; relative rate of hydrolysis;

DOI:10.1016/0031-9422(93)85084-5

Reference yield:

4-nitrophenyl α-D-galactoside (7493-95-0) → D-Galactose (10257-28-0) + 4-nitro-phenol (100-02-7,78813-13-5,89830-32-0)

Guidance literature:

With α-galactosidase; at 25 ℃; for 0.0833333h; Rate constant;

DOI:10.1016/0031-9422(81)85216-8

upstream raw materials:

Hyperoside

diazomethane

3-O-β-D-galactopyranosyl-(1->2)-<β-D-xylopyranosyl-(1->3)>-β-D-glucuronopyranosyl quillaic acid 28-O-β-D-apiofuranosyl-(1->3)-β-D-xylopyranosyl-(1->4)-<β-D-glucopyranosyl-(1->3)>-α-L-rhamnopyranosyl-(1->2)-β-D-fucopyranoside.

formaldehyd

Downstream raw materials:

D-galactonic acid

(2R,3S,4R,5S)-6-[(4,5-Diphenyl-oxazol-2-yl)-hydrazono]-hexane-1,2,3,4,5-pentaol

1-bromo-2,3,4,6-tetra-O-acetyl-D-galactopyranose

Trifluoro-acetic acid (2S,3S,4R,5S)-2-[(R)-1,2-bis-(2,2,2-trifluoro-acetoxy)-ethyl]-4,5-bis-(2,2,2-trifluoro-acetoxy)-tetrahydro-furan-3-yl ester

Refernces

• 1、 Maillard, Marc,Adewunmi, Clement O.,Hostettmann, Kurt. "75. New Triterpenoid N-Acetylglycosides with Molluscicidal Activity from Tetrapleura tetraptera TAUB". . p. 668 - 674. Retrieved 1989.
• 2、 Narantuya, S.,Batsuren, D.,Rashkes, Ya. V.,Mil'grom, E. G.. "CHEMICAL STUDY OF PLANTS OF THE MONGOLIAN FLORA. COUMARINS OF Stellera chamaejasme: THE STRUCTURE OF CHAMAEJASMOSIDE - A NEW BICOUMARIN GLYCOSIDE". . p. 197 - 199. Retrieved 1994.
• 3、 Viborg, Alexander H.,Katayama, Takane,Abou Hachem, Maher,Andersen, Mathias C.F.,Nishimoto, Mamoru,Clausen, Mads H.,Urashima, Tadasu,Svensson, Birte,Kitaoka, Motomitsu. "Distinct substrate specificities of three glycoside hydrolase family 42 β-galactosidases from Bifidobacterium longum subsp. infantis ATCC 15697". . p. 208 - 216. Retrieved 2014.
• 4、 Gupta, K. C.,Sharma, Anita,Misra, V. D.. "KINETICS OF OXIDATION OF SOME DISACCHARIDES IN AMMONIACAL MEDIUM". . p. 2887 - 2893. Retrieved 1981.
• 5、 Zhang, Xiao,Su, Yan-Fang,Chen, Lei,Huang, Xiong,Yan, Shi-Lun,Chai, Xin,Gao, Xiu-Mei. "Steroidal saponins from the rhizomes of Smilacina henryi". . p. 478 - 487. Retrieved 2013.
• 6、 Somme, Randi. "PYRUVIC ACID-CONTAINING MONO- AND OLIGO-SACCHARIDES FROM Rhizobium trifolii BART A". . p. 325 - 332. Retrieved 1980.
• 7、 Sun, Sufang,Zhao, Xiuying,Xu, Xiaobing. "Immobilization of β-Galactosidase from Aspergillus oryza on Magnetic Poly(GMA-ST) Beads". . p. 381 - 384. Retrieved 2013.
• 8、 Tchuendem, Marguerite H.K.,Douanla, Pascal D.,Tabopda, Turibio K.,Tchinda, Alembert T.,Tamze, Véronique,Nkengfack, Augustin E.,Abegaz, Berhanu M.,Connolly, Joseph D.. "Two new glycosides from Duboscia macrocarpa Bocq.". . p. 1 - 4. Retrieved 2014.
• 9、 Hess, David,Rane, Anandkumar,Demello, Andrew J.,Stavrakis, Stavros. "High-throughput, quantitative enzyme kinetic analysis in microdroplets using stroboscopic epifluorescence imaging". . p. 4965 - 4972. Retrieved 2015.
• 10、 Lanzotti, Virginia,Romano, Adriana,Lanzuise, Stefania,Bonanomi, Giuliano,Scala, Felice. "Antifungal saponins from bulbs of white onion, Allium cepa L.". . p. 133 - 139. Retrieved 2012.