Novel simple thioureas with growth hormone releasing properties

Article abstract of DOI:10.1016/S0223-5234(97)83289-8

A series of thioureas containing two aromatic groups and one amino group was synthesized as potential growth hormone secretagogues. The growth hormone (GH) releasing properties of these compounds (10-24) were evaluated using primary rat pituitary cells. The most potent compound 20 showed potency with an EC₅₀ of 1.8 μM. Two constrained analogs 23 and 24 showed similar activity.