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138112-76-2

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Agomelatine Nootropics powder
Cas No: 138112-76-2
No Data 100 Gram 500 Kilogram/Week Xi'an Yinherb Bio-Tech Co., Ltd. Contact Supplier
Agomelatine
Cas No: 138112-76-2
USD $ 1.0-1.0 / Gram 1 Gram 1 Metric Ton/Month Nanjing chemipioneer pharmaceutical & technology Co., LTD Contact Supplier
Agomelatine Manufacturer/High quality/Best price/In stock
Cas No: 138112-76-2
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Hangzhou Dayangchem Co., Ltd. Contact Supplier
High Quality Effective Agomelatine for Body Treatment
Cas No: 138112-76-2
No Data 10 Gram 10 Metric Ton/Year Hubei Jusheng Technology Co., Ltd., Contact Supplier
High purity Agomelatine CAS:138112-76-2
Cas No: 138112-76-2
USD $ 1.0-5.0 / Kilogram 1 Kilogram 99999 Kilogram/Year Hangzhou Dingyan Chem Co., Ltd Contact Supplier
High quality Agomelatine supplier in China
Cas No: 138112-76-2
No Data No Data No Data Simagchem Corporation Contact Supplier
Agomelatine
Cas No: 138112-76-2
No Data No Data No Data Shanghai Sunwise Chemical Co., Ltd Contact Supplier
Agomelatine CAS:138112-76-2
Cas No: 138112-76-2
USD $ 10.0-10.0 / Kilogram 1 Kilogram 800 Metric Ton/Month Crovell Biotech (Hebei) Co., Ltd. Contact Supplier
Agomelatine
Cas No: 138112-76-2
USD $ 2600.0-3000.0 / Kilogram 1 Kilogram 100 Kilogram/Day Chengdu Yanxi Import & Export Trading CO.,LTD Contact Supplier
High Purity 138112-76-2 Pharmaceutical Raw Materials Atypical antidepressant Pharmaceutical Agomelatine
Cas No: 138112-76-2
USD $ 0.5-1.0 / Kilogram 1 Kilogram 3000 Kilogram/Day Wuhan Demeikai Biotechnology Co., Ltd Contact Supplier

138112-76-2 Usage

Pharmacological effects

The listing of agomelatine is a new breakthrough in the field of the treatment of depression. It is melatonin MT1/MT2 receptor agonist and serotonin 2c (5-HT2C) receptor antagonist. It can make depressed patients’ biological rhythm disorders return to normal through the synergy between the two and then result in antidepressant efficacy. Its unique mechanism of action has opened up an innovative way to treat depression. Agomelatine’s mechanism of drug action is completely different with antidepressants that are commonly used today, such as selective serotonin reuptake inhibitors (SSRI) and serotonin-norepinephrine reuptake inhibitors (SNRI). SSRI and SNRI antidepressants achieve antidepressant efficacy by increasing concentration of serotonin. But it also brings a lot of side effects, such as weight changes, sexual dysfunction, withdrawal syndrome and the like. The molecular structure of agomelatine directly combines with serotonin 2c (5HT2c) receptor of post-synaptic membrane so as to exert its antidepressant efficacy without increasing serotonin concentration in the synaptic cleft. This unique mechanism of action makes agomelatine quickly and effectively exert its antidepressant efficacy at the same time, and avoid the occurrence of adverse drug reactions to an extreme.
Another unique targets of agomelatine is in melatonin receptors. MT1 and MT2 receptors densely distribute in the human suprachiasmatic nucleus. The nucleus mainly control human sleep rhythm. Agomelatine can well improve the quality of patients’ sleep by agonism on MT1 MT2 receptors, and improve patients’ wakefulness during the day. The quality of sleep has both cause and effect relationship with depression outcomes state. It is reported that 80% of patients with depression have the problems of sleep disorders at different levels. The improvement of sleep quality can directly contribute to the improvement of the overall clinical condition of patients with depression.
The above information is edited by the Chemicalbook of Ge Qian.

Uses

Agomelatine is an antidepressant drug. It is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor. Activation of 5-HT2C receptors by serotonin inhibits dopamine and norepinephrine release. Antagonism of

Patent cases

The earliest agomelatine compound patent is French Patent FR902393, which is applied in February 27, 1990. This patent has the same patent family in Europe, USA, Canada, Japan and Australia. But there is no Chinese patent. The above patents were all authorized after January 1, 1993. Therefore China is also ineligible for administrative protection. Agomelatine has both technology patent and polymorph patent in China. But it also can be avoided.

Health risk

October 30, 2012, the British Medicines and Healthcare Products Agency (MHRA) released agomelatine (agomelatine, Valdoxan/Thymanax) security information. MHRA found that several cases appears serious reports of liver toxicity with agomelatine, including six cases of liver failure patients within worldwide report. Agomelatine's drug information already includes in the recommendations that all patients need liver function tests at the start of treatment and during treatment. Now liver function tests should also be recommended when the drug dose is increased. MHRA recommends that if the patients have potential liver damage symptoms or signs, or that the increases of serum transaminase beyond the upper limit of normal (ULN) three times is found in the function tests, it should be immediately suspended.

Chemical Properties

White Solid

Uses

Agomelatine is a melatoninergic agonist and selective antagonist of 5-HT2C receptors, and has been shown to be active in several animal models of depression. Agomelatine (S20098) displayed pKi values of 6.4 and 6.2 at native (porcine) and cloned, human (h)5-hydroxytryptamine (5-HT)2C receptors, respectively.

Antidepressants

Agomelatine, which is developed by the French Servier company, is the world's first melatonin receptors MT1 and MT2 agonist class of antidepressants. It applies to the treatment of adult patients with severe depressive. We know that melatonin is an endogenous neural hormones. It is only produced by the pineal gland anterior pituitary at night, and acts on the melatonin receptor that focuses on the presence of hypothalamic suprachiasmatic nucleus (SCN). It is involved in mediating the circadian rhythms in mammals. It is the well-known time guardian in the body, which can regulate the biological clock that is modulated by external circadian cycle. However, since that melatonin has high catabolism rate in vivo which mikes its half-life shorter and the selectivity of its receptor located in the SCN poorer, the treatment of circadian rhythms disorders is limited. Therefore, in order to overcome these drawbacks of melatonin, the researchers designed a series of melatonin analogues. Molecular modeling studies have shown that indole ring of melatonin is the structure sites of catabolic inactivation. Indole ring is an ideal site of isosteric modifications. Agomelatine developed by Servier company is melatonin’s naphthalene biological (electronic) isostere analogs. Indole ring is substituted by naphthalene nucleus, which leads it have more metabolic stability than melatonin.

Uses

Melatonin drugs.

138112-76-2 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Sigma (A1362)  Agomelatine  ≥98% (HPLC) 138112-76-2 A1362-25MG 2,819.70CNY Detail
Sigma (A1362)  Agomelatine  ≥98% (HPLC) 138112-76-2 A1362-5MG 700.83CNY Detail
TCI America (A2606)  Agomelatine  >98.0%(HPLC)(N) 138112-76-2 1g 1,390.00CNY Detail

138112-76-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name Agomelatine

1.2 Other means of identification

Product number -
Other names N-[2-(7-Methoxy-1-naphthalenyl)ethyl]-acetamide S-20098

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:138112-76-2 SDS

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