
Tetrahedron Letters p. 2471 - 2474 (1998)
Update date:2022-08-11
Topics:
Salmoria, Gean V.
Dall'Oglio, Evandro
Zucco, Cesar
In order to study the effect of microwave irradiation over aromatic nucleophilic substitutions at atmospheric pressure and in a homogeneous medium, experiments with disubstituted-benzenes and the nucleophiles piperidine and potassium t-butoxide, in refluxing DMSO or DMF, were carried out. The aromatic nucleophilic substitutions under microwave irradiation were 2.7 to 12 times faster than under conventional reflux.
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