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| CAS No.: | 73-22-3 |
|---|---|
| Name: | L-Tryptophane |
| Molecular Structure: | |
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| Formula: | C11H12N2O2 |
| Molecular Weight: | 204.228 |
| Synonyms: | L(-)-Tryptophan;EH 121;l-alpha-Aminoindole-3-propionic acid;(S)-alpha-Amino-beta-(3-indolyl)-propionic acid;Sedanoct;L-Tryptophan (JP14);L-Trp;(S)-alpha-Amino-beta-indolepropionic acid;NCI-C01729;(S)-2-Amino-3-(3-indolyl)propionic acid;(-)-Tryptophan;(S)-alpha-Aminoindole-3-propionic acid;(2S)-2-azaniumyl-3-(1H-indol-3-yl)propanoate;Tryptophan, L-;2-Amino-3-indolylpropanoic acid;WV;Pacitron;Indole-3-alanine;1H-Indole-3-propanoic acid, alpha-amino-, (S)-;(S)-Tryptophan;Alanine, 3-indol-3-yl;L-(-)-Tryptophan;Triptofano [Spanish];3-Indol-3-ylalanine;Ardeytropin;L-alpha-Amino-3-indolepropionic acid;(S)-alpha-Amino-1H-indole-3-propanoic acid;Tryptophan (VAN);alpha-Amino-3-indolepropionic acid, L-;Tryptophanum [Latin];L-Alanine, 3-(1H-indol-3-yl)-;L-Tryptophan (9CI); |
| EINECS: | 200-795-6 |
| Density: | 1.363 g/cm3 |
| Melting Point: | 289-290 °C (dec.)(lit.) |
| Boiling Point: | 447.908 °C at 760 mmHg |
| Flash Point: | 224.687 °C |
| Solubility: | 11.4 g/L (25°C) in water |
| Appearance: | White to off-white crystalline powder |
| Hazard Symbols: |
 Xi
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| Risk Codes: | 33-40-62-41-37/38-36/37/38-22 |
| Safety: | 24/25-36/37/39-36-26 |
| PSA: | 79.11000 |
| LogP: | 1.82260 |
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Consensus Reports
NCI Carcinogenesis Bioassay (feed); No Evidence: mouse, rat NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-71 ,1978. . Reported in EPA TSCA Inventory.
Specification
The L-Tryptophan, with the CAS registry number 73-22-3,is also known as L(-)-Tryptophan; (S)-2-Amino-3-(1H-indol-3-yl)propanoic acid. It belongs to the product categories of Amino Acids;Amino Acids & Derivatives. This chemical's molecular formula is C11H12N2O2 and molecular weight is 204.23.Its EINECS number is 200-795-6. What's more,Its systematic name is L-Tryptophan. It is a white to off-white crystalline powder which is stable,incompatible with strong acids, strong oxidizing agents.And it can be improvement nutrition and enhancement physique. It is also uses in the biochemistry research, and it is used as sedative in the medicine.
Physical properties about L-Tryptophan are:
(1)ACD/LogP: 0.704; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -1.80; (4)ACD/LogD (pH 7.4): -1.80; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 1.00; (8)ACD/KOC (pH 7.4): 1.00; (9)#H bond acceptors: 4; (10)#H bond donors: 4; (11)#Freely Rotating Bonds: 4; (12)Index of Refraction: 1.698; (13)Molar Refractivity: 57.769 cm3; (14)Molar Volume: 149.875 cm3; (15)Polarizability: 22.901×10-24 cm3 ; (16)Surface Tension: 71.1620025634766 dyne/cm; (17)Density: 1.363 g/cm3; (18)Flash Point: 224.687 °C; (19)Enthalpy of Vaporization: 74.437 kJ/mol; (20)Boiling Point: 447.908 °C at 760 mmHg; (21)Vapour Pressure: 0 mmHg at 25°C.
You could convert the following datas into the molecular structure:
(1)SMILES:c1ccc2c(c1)c(c[nH]2)C[C@@H](C(=O)O)N;
(2)Std. InChI:InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1;
(3)Std. InChIKey:QIVBCDIJIAJPQS-VIFPVBQESA-N.
The toxicity data of L-Tryptophan are as follows:
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| bird - domestic | LD50 | intraperitoneal | 2410mg/kg (2410mg/kg) | Drugs in Japan Vol. -, Pg. 744, 1990. | |
| man | TDLo | oral | 300mg/kg (300mg/kg) | BEHAVIORAL: EXCITEMENT BEHAVIORAL: ANTIANXIETY | British Medical Journal. Vol. 2, Pg. 701, 1976. |
| man | TDLo | oral | 857mg/kg/30D- (857mg/kg) | BLOOD: EOSINOPHILIA SKIN AND APPENDAGES (SKIN): OTHER GLANDS: OTHER MUSCULOSKELETAL: OTHER CHANGES | New England Journal of Medicine. Vol. 322, Pg. 874, 1990. |
| mouse | LD50 | intraperitoneal | 4800mg/kg (4800mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: CYANOSIS | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 11, Pg. 635, 1980. |
| mouse | LDLo | oral | 15gm/kg (15000mg/kg) | SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE LUNGS, THORAX, OR RESPIRATION: CYANOSIS | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 11, Pg. 635, 1980. |
| rat | LD50 | intraperitoneal | 1634mg/kg (1634mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Archives of Biochemistry and Biophysics. Vol. 58, Pg. 253, 1955. |
| rat | LD50 | oral | > 16gm/kg (16000mg/kg) | SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: COMA | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 11, Pg. 635, 1980. |
| rat | LDLo | unreported | 2553mg/kg (2553mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 23, Pg. 884, 1973. | |
| women | TDLo | oral | 2700mg/kg/13W (2700mg/kg) | LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA BLOOD: EOSINOPHILIA | Annals of Internal Medicine. Vol. 112, Pg. 301, 1990. |
| women | TDLo | oral | 3276mg/kg/9W- (3276mg/kg) | BEHAVIORAL: MUSCLE WEAKNESS BLOOD: EOSINOPHILIA SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" | Annals of Internal Medicine. Vol. 112, Pg. 344, 1990. |
| women | TDLo | oral | 4800mg/kg/34W (4800mg/kg) | PERIPHERAL NERVE AND SENSATION: PARESTHESIS SKIN AND APPENDAGES (SKIN): OTHER GLANDS: OTHER BLOOD: EOSINOPHILIA | New England Journal of Medicine. Vol. 322, Pg. 874, 1990. |
| women | TDLo | oral | 5400mg/kg/134 (5400mg/kg) | BLOOD: EOSINOPHILIA SKIN AND APPENDAGES (SKIN): OTHER GLANDS: OTHER | New England Journal of Medicine. Vol. 322, Pg. 874, 1990. |
| women | TDLo | oral | 9gm/kg/22W-I (9000mg/kg) | BEHAVIORAL: MUSCLE WEAKNESS LIVER: LIVER FUNCTION TESTS IMPAIRED BLOOD: EOSINOPHILIA | Annals of Internal Medicine. Vol. 112, Pg. 957, 1990. |
| women | TDLo | oral | 10960mg/kg/20 (10960mg/kg) | BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA BLOOD: EOSINOPHILIA | British Medical Journal. Vol. 301, Pg. 21, 1990. |
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