CAS No.73-22-3,L-Tryptophane Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	73-22-3
Name:	L-Tryptophane
Article Data:	197
Cas Database

Formula:	C₁₁H₁₂N₂O₂
Molecular Weight:	204.228
Synonyms:	L(-)-Tryptophan;EH 121;l-alpha-Aminoindole-3-propionic acid;(S)-alpha-Amino-beta-(3-indolyl)-propionic acid;Sedanoct;L-Tryptophan (JP14);L-Trp;(S)-alpha-Amino-beta-indolepropionic acid;NCI-C01729;(S)-2-Amino-3-(3-indolyl)propionic acid;(-)-Tryptophan;(S)-alpha-Aminoindole-3-propionic acid;(2S)-2-azaniumyl-3-(1H-indol-3-yl)propanoate;Tryptophan, L-;2-Amino-3-indolylpropanoic acid;WV;Pacitron;Indole-3-alanine;1H-Indole-3-propanoic acid, alpha-amino-, (S)-;(S)-Tryptophan;Alanine, 3-indol-3-yl;L-(-)-Tryptophan;Triptofano [Spanish];3-Indol-3-ylalanine;Ardeytropin;L-alpha-Amino-3-indolepropionic acid;(S)-alpha-Amino-1H-indole-3-propanoic acid;Tryptophan (VAN);alpha-Amino-3-indolepropionic acid, L-;Tryptophanum [Latin];L-Alanine, 3-(1H-indol-3-yl)-;L-Tryptophan (9CI);
EINECS:	200-795-6
Density:	1.363 g/cm³
Melting Point:	289-290 °C (dec.)(lit.)
Boiling Point:	447.908 °C at 760 mmHg
Flash Point:	224.687 °C
Solubility:	11.4 g/L (25°C) in water
Appearance:	White to off-white crystalline powder
Hazard Symbols:	Xi
Risk Codes:	33-40-62-41-37/38-36/37/38-22
Safety:	24/25-36/37/39-36-26
PSA:	79.11000
LogP:	1.82260

Consensus Reports

NCI Carcinogenesis Bioassay (feed); No Evidence: mouse, rat NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-71 ,1978. . Reported in EPA TSCA Inventory.

Specification

The L-Tryptophan, with the CAS registry number 73-22-3,is also known as L(-)-Tryptophan; (S)-2-Amino-3-(1H-indol-3-yl)propanoic acid. It belongs to the product categories of Amino Acids;Amino Acids & Derivatives. This chemical's molecular formula is C₁₁H₁₂N₂O₂ and molecular weight is 204.23.Its EINECS number is 200-795-6. What's more,Its systematic name is L-Tryptophan. It is a white to off-white crystalline powder which is stable,incompatible with strong acids, strong oxidizing agents.And it can be improvement nutrition and enhancement physique. It is also uses in the biochemistry research, and it is used as sedative in the medicine.

Physical properties about L-Tryptophan are:
(1)ACD/LogP: 0.704; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -1.80; (4)ACD/LogD (pH 7.4): -1.80; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 1.00; (8)ACD/KOC (pH 7.4): 1.00; (9)#H bond acceptors: 4; (10)#H bond donors: 4; (11)#Freely Rotating Bonds: 4; (12)Index of Refraction: 1.698; (13)Molar Refractivity: 57.769 cm³; (14)Molar Volume: 149.875 cm³; (15)Polarizability: 22.901×10^-24cm³ ; (16)Surface Tension: 71.1620025634766 dyne/cm; (17)Density: 1.363 g/cm³; (18)Flash Point: 224.687 °C; (19)Enthalpy of Vaporization: 74.437 kJ/mol; (20)Boiling Point: 447.908 °C at 760 mmHg; (21)Vapour Pressure: 0 mmHg at 25°C.

You could convert the following datas into the molecular structure:
(1)SMILES:c1ccc2c(c1)c(c[nH]2)C[C@@H](C(=O)O)N;
(2)Std. InChI:InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1;
(3)Std. InChIKey:QIVBCDIJIAJPQS-VIFPVBQESA-N.

The toxicity data of L-Tryptophan are as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
bird - domestic	LD50	intraperitoneal	2410mg/kg (2410mg/kg)		Drugs in Japan Vol. -, Pg. 744, 1990.
man	TDLo	oral	300mg/kg (300mg/kg)	BEHAVIORAL: EXCITEMENT BEHAVIORAL: ANTIANXIETY	British Medical Journal. Vol. 2, Pg. 701, 1976.
man	TDLo	oral	857mg/kg/30D- (857mg/kg)	BLOOD: EOSINOPHILIA SKIN AND APPENDAGES (SKIN): OTHER GLANDS: OTHER MUSCULOSKELETAL: OTHER CHANGES	New England Journal of Medicine. Vol. 322, Pg. 874, 1990.
mouse	LD50	intraperitoneal	4800mg/kg (4800mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 11, Pg. 635, 1980.
mouse	LDLo	oral	15gm/kg (15000mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 11, Pg. 635, 1980.
rat	LD50	intraperitoneal	1634mg/kg (1634mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Archives of Biochemistry and Biophysics. Vol. 58, Pg. 253, 1955.
rat	LD50	oral	> 16gm/kg (16000mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: COMA	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 11, Pg. 635, 1980.
rat	LDLo	unreported	2553mg/kg (2553mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 23, Pg. 884, 1973.
women	TDLo	oral	2700mg/kg/13W (2700mg/kg)	LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA BLOOD: EOSINOPHILIA	Annals of Internal Medicine. Vol. 112, Pg. 301, 1990.
women	TDLo	oral	3276mg/kg/9W- (3276mg/kg)	BEHAVIORAL: MUSCLE WEAKNESS BLOOD: EOSINOPHILIA SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	Annals of Internal Medicine. Vol. 112, Pg. 344, 1990.
women	TDLo	oral	4800mg/kg/34W (4800mg/kg)	PERIPHERAL NERVE AND SENSATION: PARESTHESIS SKIN AND APPENDAGES (SKIN): OTHER GLANDS: OTHER BLOOD: EOSINOPHILIA	New England Journal of Medicine. Vol. 322, Pg. 874, 1990.
women	TDLo	oral	5400mg/kg/134 (5400mg/kg)	BLOOD: EOSINOPHILIA SKIN AND APPENDAGES (SKIN): OTHER GLANDS: OTHER	New England Journal of Medicine. Vol. 322, Pg. 874, 1990.
women	TDLo	oral	9gm/kg/22W-I (9000mg/kg)	BEHAVIORAL: MUSCLE WEAKNESS LIVER: LIVER FUNCTION TESTS IMPAIRED BLOOD: EOSINOPHILIA	Annals of Internal Medicine. Vol. 112, Pg. 957, 1990.
women	TDLo	oral	10960mg/kg/20 (10960mg/kg)	BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA BLOOD: EOSINOPHILIA	British Medical Journal. Vol. 301, Pg. 21, 1990.

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